Lacut Karine, Oger Emmanuel
Groupe d'étude de la thrombose de Bretagne occidentale, GETBO--EA 3878, département de médecine interne et pneumologie, hôpital de la Cavale blanche, 29609 Brest Cedex.
Rev Prat. 2005 Feb 28;55(4):389-92.
Oral estrogens are associated with a two-fold to three-fold increased risk of venous thromboembolism in postmenopausal women. Absolute excess risk is low but higher than for contraceptive pills. Biological data and observational studies suggest that transdermal estrogens are associated with a lower risk for venous thromboembolism than oral estrogens but safety has yet to be proved. Whether addition of progestin plays a significant role is undetermined so far.
口服雌激素会使绝经后女性发生静脉血栓栓塞的风险增加两倍至三倍。绝对超额风险较低，但高于避孕药。生物学数据和观察性研究表明，经皮雌激素与静脉血栓栓塞的风险低于口服雌激素，但安全性尚未得到证实。到目前为止，添加孕激素是否起重要作用尚不确定。
