Barbiro-Michaely Efrat, Mayevsky Avraham, Knoller Nachshon, Hadani Moshe
Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Neurol Res. 2005 Jan;27(1):88-93. doi: 10.1179/016164105X18377.
Over the last 20 years, mannitol has replaced other osmotic diuretics. Its beneficial effects on intracranial pressure (ICP), cerebral perfusion pressure (CPP), cerebral blood flow (CBF) and brain metabolism are widely accepted. In the present study, we tested the effect of mannitol injection on brain hemodynamic, metabolic, ionic and electrical state in rats exposed to intracranial hypertension.
The parameters monitored simultaneously included ICP, CBF using the laser Doppler flowmetry, mitochondrial NADH redox state by the fluorometric technique, extracellular K(+) and H(+) levels, DC potential, ECoG, blood pressure and calculated CPP. ICP was elevated to 30 mmHg for 30 minutes and mannitol was injected 15 minutes post-ICP elevation.
Our results showed that mannitol decreased ICP, and improved the levels of MAP, CPP and CBF. Moreover, mannitol completely prevented mortality following intracranial hypertension in rats.
It seems that the multiparametric monitoring approach, used in intracranial hypertension models, is an important tool for brain functional state evaluation.
在过去20年中，甘露醇已取代其他渗透性利尿剂。其对颅内压（ICP）、脑灌注压（CPP）、脑血流量（CBF）和脑代谢的有益作用已被广泛认可。在本研究中，我们测试了甘露醇注射对颅内高压大鼠脑血流动力学、代谢、离子和电状态的影响。
同时监测的参数包括ICP、使用激光多普勒血流仪测量的CBF、通过荧光技术测量的线粒体NADH氧化还原状态、细胞外K(+)和H(+)水平、直流电位、脑电图（ECoG）、血压和计算得出的CPP。将ICP升高至30 mmHg持续30分钟，并在ICP升高后15分钟注射甘露醇。
我们的结果表明，甘露醇降低了ICP，并改善了平均动脉压（MAP）、CPP和CBF水平。此外，甘露醇完全预防了大鼠颅内高压后的死亡。
似乎在颅内高压模型中使用的多参数监测方法是评估脑功能状态的重要工具。
