Rice L, Ott E A, Beede D K, Wilcox C J, Johnson E L, Lieb S, Borum P
Department of Biochemistry, University of Florida, Gainesville 32611.
J Anim Sci. 1992 Apr;70(4):1175-81. doi: 10.2527/1992.7041175x.
Oral tolerance tests were performed on 13 neonatal foals to determine their ability to digest disaccharides on d 1, 3 and 5 postpartum. Foals were assigned randomly to treatments consisting of 20% (wt/vol) solutions of either maltose, lactose, or sucrose, dosed at 1 g/kg of BW, or glucose, dosed at .5 g/kg of BW. After a 2-h fast, an initial blood sample was collected via jugular catheter. Foals were administered the appropriate solution orally, and blood was collected every 15 min for 1 h and then every 30 min for 3 h. Plasma glucose increased after dosing with lactose or glucose but not with sucrose. Plasma glucose concentrations increased slightly on d 3 and 5 in foals dosed with maltose. These findings suggest that although lactose is well digested by neonatal foals, maltose is digested only slightly, and sucrose is not digested by d 5. Results of this experiment indicate that maltose and sucrose would not be suitable for inclusion in artificial diets for foals less than 1 wk old. Oral tolerance tests could be useful for determining the ability of premature or sick foals with lactose intolerance to digest alternate carbohydrate sources.
对13只新生马驹进行了口服耐受性测试，以确定它们在产后第1天、第3天和第5天消化双糖的能力。马驹被随机分配到不同处理组，分别给予20%（重量/体积）的麦芽糖、乳糖或蔗糖溶液（剂量为1 g/kg体重），或葡萄糖溶液（剂量为0.5 g/kg体重）。禁食2小时后，通过颈静脉导管采集初始血样。给马驹口服相应溶液，然后每15分钟采集一次血样，持续1小时，之后每30分钟采集一次血样，持续3小时。给予乳糖或葡萄糖后血浆葡萄糖升高，但给予蔗糖后未升高。用麦芽糖给药的马驹在第3天和第5天血浆葡萄糖浓度略有升高。这些发现表明，虽然新生马驹能很好地消化乳糖，但麦芽糖仅被少量消化，到第5天蔗糖仍未被消化。本实验结果表明，麦芽糖和蔗糖不适用于添加到小于1周龄马驹的人工饲料中。口服耐受性测试可能有助于确定乳糖不耐受的早产或患病马驹消化替代碳水化合物来源的能力。
