极低出生体重儿念珠菌血症存活者眼内炎患病率极低。
Very low prevalence of endophthalmitis in very low birthweight infants who survive candidemia.
作者信息
Fisher Randall G, Gary Karlowicz Mitchell, Lall-Trail Joel
机构信息
Department of Pediatrics, Eastern Virginia Medical School, Children's Hospital of The King's Daughters, Norfolk, 23507, USA.
出版信息
J Perinatol. 2005 Jun;25(6):408-11. doi: 10.1038/sj.jp.7211300.
OBJECTIVE
Candida species often cause sepsis in very low birthweight (VLBW) infants, leading to formal ophthalmologic evaluation for endophthalmitis. Our experience suggests that endophthalmitis is rare in this setting, and retinal vascular compromise in extreme prematurity may decrease the risk. We studied the prevalence of endophthalmitis in surviving VLBW infants with candidemia.
STUDY DESIGN
Epidemiologic data and presence of ROP and endophthalmitis were ascertained for all VLBW infants with candidemia at our institution from 1994 to 2001.
RESULTS
A total of 123 infants were included. Median EGA was 25 weeks (range, 23 to 32) and median birthweight was 735 g (range, 426 to 1460). Of these 123, only one had transient retinal findings (prevalence 0.8%; 95% confidence interval 0 to 4%), which resolved during therapy. In no case was either the duration of therapy or the outcome of candidemia altered by retinal examination.
CONCLUSIONS
Aggressive treatment of candidemia has made endogenous endophthalmitis rare in candidemic VLBW infants.
目的
念珠菌属常导致极低出生体重（VLBW）婴儿发生败血症，从而需要进行正式的眼科检查以评估是否患有眼内炎。我们的经验表明，在这种情况下眼内炎很少见，极端早产时视网膜血管受损可能会降低风险。我们研究了存活的患念珠菌血症的极低出生体重婴儿眼内炎的患病率。
研究设计
确定了1994年至2001年在我们机构中所有患念珠菌血症的极低出生体重婴儿的流行病学数据以及视网膜病变（ROP）和眼内炎的情况。
结果
共纳入123名婴儿。平均孕周为25周（范围23至32周），平均出生体重为735克（范围426至1460克）。在这123名婴儿中，只有1名有短暂的视网膜病变表现（患病率0.8%；95%置信区间0至4%），在治疗过程中病变消失。视网膜检查未改变任何一例的治疗时长或念珠菌血症的转归。
结论
积极治疗念珠菌血症已使患念珠菌血症的极低出生体重婴儿内源性眼内炎变得罕见。
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