在健康供体中使用粒细胞集落刺激因子（G-CSF）进行动员可促进基因的高度但短暂的失调。 - Suppr

Mobilisation with G-CSF in healthy donors promotes a high but temporal deregulation of genes.

作者信息

Hernández J M, Castilla C, Gutiérrez N C, Isidro I M, Delgado M, de las Rivas J, Fermiñán E, García J L, Ocio E M, del Cañizo M C, San Miguel J F

出版信息

Leukemia. 2005 Jun;19(6):1088-91. doi: 10.1038/sj.leu.2403753.

DOI:10.1038/sj.leu.2403753

PMID:15830010

Abstract

摘要

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Mobilisation with G-CSF in healthy donors promotes a high but temporal deregulation of genes.在健康供体中使用粒细胞集落刺激因子（G-CSF）进行动员可促进基因的高度但短暂的失调。

Leukemia. 2005 Jun;19(6):1088-91. doi: 10.1038/sj.leu.2403753.

Factors predicting allogeneic PBSCs yield after G-CSF treatment in healthy donors.预测健康供者经粒细胞集落刺激因子（G-CSF）治疗后异基因外周血干细胞产量的因素。

Bone Marrow Transplant. 2009 Nov;44(9):613-5. doi: 10.1038/bmt.2009.60. Epub 2009 Mar 23.

Pegylated granulocyte colony-stimulating factor mobilizes CD34+ cells with different stem and progenitor subsets and distinct functional properties in comparison with unconjugated granulocyte colony-stimulating factor.与未缀合的粒细胞集落刺激因子相比，聚乙二醇化粒细胞集落刺激因子动员具有不同干细胞和祖细胞亚群以及不同功能特性的CD34+细胞。

Haematologica. 2008 Mar;93(3):347-55. doi: 10.3324/haematol.12081. Epub 2008 Feb 11.

Factors associated with granulocyte colony-stimulating factor-induced peripheral blood stem cell yield in healthy donors.健康供体中与粒细胞集落刺激因子诱导的外周血干细胞产量相关的因素。

Vox Sang. 2005 Nov;89(4):229-35. doi: 10.1111/j.1423-0410.2005.00701.x.

[Collection of hematopoietic progenitor cells from healthy donors].[从健康供体采集造血祖细胞]

Acta Med Croatica. 2009 Jun;63(3):237-44.

Acute lung Injury in a healthy donor during mobilization of peripheral blood stem cells using granulocyte-colony stimulating factor alone.仅使用粒细胞集落刺激因子动员外周血干细胞期间健康供体发生的急性肺损伤。

Haematologica. 2005 Mar;90(3):ECR10.

Detection and quantification of functionally defined hematopoietic progenitor cells and tissue specific mRNA within the peripheral blood of myeloma patients after administration of granulocyte colony-stimulating factor and erythropoietin.在给予粒细胞集落刺激因子和促红细胞生成素后，对骨髓瘤患者外周血中功能明确的造血祖细胞和组织特异性mRNA进行检测和定量分析。

Eur J Haematol. 2008 Jan;80(1):20-30. doi: 10.1111/j.1600-0609.2007.00983.x. Epub 2007 Nov 19.

The role of granulocyte colony-stimulating factor in mobilization and transplantation of peripheral blood progenitor and stem cells .粒细胞集落刺激因子在外周血祖细胞和干细胞动员及移植中的作用

Cytokines Mol Ther. 1995 Dec;1(4):249-70.

Changes in gene expression pattern following granulocyte colony-stimulating factor administration to normal stem cell sibling donors.向正常干细胞同胞供体施用粒细胞集落刺激因子后基因表达模式的变化。

Acta Haematol. 2007;117(2):68-73. doi: 10.1159/000096856. Epub 2006 Nov 9.

Pulmonary micro-embolism in a healthy donor following G-CSF administration for mobilization of hemopoietic progenitor cells.

Bone Marrow Transplant. 2012 Feb;47(2):308-10. doi: 10.1038/bmt.2011.72. Epub 2011 Apr 4.

引用本文的文献

Long-term follow-up of cancer and catastrophic diseases in hematopoietic stem cell donors: a comprehensive matched cohort study.造血干细胞供者中癌症和灾难性疾病的长期随访：一项全面匹配队列研究。

Bone Marrow Transplant. 2024 Jun;59(6):849-857. doi: 10.1038/s41409-024-02204-7. Epub 2024 Mar 7.

Cancer incidence in healthy Swedish peripheral blood stem cell donors.健康的瑞典外周血造血干细胞供者的癌症发病率。

Bone Marrow Transplant. 2022 May;57(5):795-802. doi: 10.1038/s41409-022-01617-6. Epub 2022 Mar 7.

Transient thrombocytopenia in a cat following G-CSF treatment.猫在接受 G-CSF 治疗后出现一过性血小板减少症。

Vet Med Sci. 2022 Mar;8(2):421-424. doi: 10.1002/vms3.706. Epub 2021 Dec 29.

An Overview on Promising Somatic Cell Sources Utilized for the Efficient Generation of Induced Pluripotent Stem Cells.用于高效诱导多能干细胞生成的有前景的体细胞来源概述

Stem Cell Rev Rep. 2021 Dec;17(6):1954-1974. doi: 10.1007/s12015-021-10200-3. Epub 2021 Jun 7.

Is It Better to Mobilize Hematopoietic Stem Cells With Pegfilgrastim in Healthy Donors During Allogeneic Hematopoietic Stem Cell Transplantation?在异基因造血干细胞移植中，使用聚乙二醇化重组人粒细胞刺激因子动员健康供体的造血干细胞是否更好？

Front Oncol. 2020 Sep 3;10:1598. doi: 10.3389/fonc.2020.01598. eCollection 2020.

G-CSF-induced severe thrombocytopenia in a healthy donor: A rare case report.健康供者中粒细胞集落刺激因子诱导的严重血小板减少症：一例罕见病例报告

Medicine (Baltimore). 2019 Mar;98(12):e14786. doi: 10.1097/MD.0000000000014786.

Granulocyte colony-stimulating factor alters the systemic metabolomic profile in healthy donors.粒细胞集落刺激因子改变健康供体的全身代谢组学特征。

Metabolomics. 2017;13(1):2. doi: 10.1007/s11306-016-1139-x. Epub 2016 Nov 28.

Granulocyte colony-stimulating factor impairs CD8(+) T cell functionality by interfering with central activation elements.粒细胞集落刺激因子通过干扰中枢激活元件损害CD8(+) T细胞功能。

Clin Exp Immunol. 2016 Jul;185(1):107-18. doi: 10.1111/cei.12794. Epub 2016 May 13.

A review of the genetic and long-term effects of G-CSF injections in healthy donors: a reassuring lack of evidence for the development of haematological malignancies.健康供体中粒细胞集落刺激因子注射的遗传及长期影响综述：尚无确凿证据表明会引发血液系统恶性肿瘤

Bone Marrow Transplant. 2015 Mar;50(3):334-40. doi: 10.1038/bmt.2014.278. Epub 2015 Jan 19.

Impaired functionality of antiviral T cells in G-CSF mobilized stem cell donors: implications for the selection of CTL donor.粒细胞集落刺激因子动员的干细胞供体中抗病毒T细胞功能受损：对细胞毒性T淋巴细胞供体选择的影响

PLoS One. 2013 Dec 4;8(12):e77925. doi: 10.1371/journal.pone.0077925. eCollection 2013.

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Mobilisation with G-CSF in healthy donors promotes a high but temporal deregulation of genes.

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