Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea.
Department of Veterinary Internal Medicine, College of Veterinary Medicine and Research Institute of Veterinary Research, Jeju National University, Jeju, Korea.
Vet Med Sci. 2022 Mar;8(2):421-424. doi: 10.1002/vms3.706. Epub 2021 Dec 29.
A 4-year-old, castrated male, Russian blue cat with idiopathic epilepsy was diagnosed with neutropenia. The neutropenia was classified as idiopathic after blood tests and abdominal imaging did not reveal an infectious, inflammatory or neoplastic aetiology. As a treatment trial for idiopathic neutropenia, the cat was administered granulocyte colony-stimulating factor by subcutaneous injection once daily for 3 days. Two weeks after completion of granulocyte colony-stimulating factor therapy, the cat developed severe thrombocytopenia, with the granulocyte colony-stimulating factor therapy considered to be the most likely cause. No treatment was initiated, and the thrombocytopenia had resolved spontaneously by 2 weeks after diagnosis. This is the first reported case of transient severe thrombocytopenia in a cat following granulocyte colony-stimulating factor treatment.
一只 4 岁已去势的雄性俄罗斯蓝猫，患有特发性癫痫，被诊断为中性粒细胞减少症。经过血液检查和腹部成像，未发现感染、炎症或肿瘤病因，因此将中性粒细胞减少症归类为特发性。作为特发性中性粒细胞减少症的治疗试验，该猫每天经皮下注射粒细胞集落刺激因子一次，共 3 天。粒细胞集落刺激因子治疗完成后两周，该猫出现严重血小板减少症，粒细胞集落刺激因子治疗被认为是最可能的原因。未进行治疗，血小板减少症在诊断后 2 周内自发缓解。这是首例报道的猫在接受粒细胞集落刺激因子治疗后出现短暂严重血小板减少症的病例。
