Han Song Yup, Yoon Soo Han, Cho Ki Hong, Cho Han Jin, An Jeong Ho, Ra Young Sin
Department of Neurosurgery, School of Medicine, Ajou University, Suwon 442-721, Korea.
J Korean Med Sci. 2005 Apr;20(2):297-301. doi: 10.3346/jkms.2005.20.2.297.
The authors developed a biodegradable polymer that releases an antibiotic (nalidixic acid) slowly and continuously, for prevention of catheter-induced infection during drainage of cerebrospinal fluid. We investigated the in vitro antibiotic releasing characteristics and bacterial killing effects of the new polymer against E. coli. The novel fluoroquinolone polymer was prepared using diisopropylcarbodiimide, poly (e-capro-lactone) diol, and nalidixic acid. FT-IR, mass spectrometry, and elemental analysis proved that the novel antibacterial polymer was prepared successfully without any side products. Negative MS showed that the released drug has a similar molecular weight (M.W.=232, 350) to pure drug (M.W.=232). In high pressure liquid chromatography, the released drug and drug-oligomer showed similar retention times (about 4.5-5 min) in comparison to pure drug (4.5 min). The released nalidixic acid and nalidixic acid derivatives have antibacterial characteristics against E. Coli, Staphylococcus aureus, and Salmonella typhi, of more than 3 months duration. This study suggests the possibility of applying this new polymer to manufacture drainage catheters that resist catheter-induced infection, by delivering antibiotics for a longer period of more than 1 month.
作者研发了一种可生物降解的聚合物，其能缓慢且持续地释放抗生素（萘啶酸），用于预防脑脊液引流过程中导管引发的感染。我们研究了这种新型聚合物对大肠杆菌的体外抗生素释放特性及杀菌效果。新型氟喹诺酮聚合物是用二异丙基碳二亚胺、聚（ε-己内酯）二醇和萘啶酸制备而成的。傅里叶变换红外光谱、质谱和元素分析证明成功制备了无任何副产物的新型抗菌聚合物。负离子质谱显示释放出的药物与纯药物分子量相似（分子量=232、350）（纯药物分子量=232）。在高压液相色谱中，与纯药物（4.5分钟）相比，释放出的药物和药物低聚物显示出相似的保留时间（约4.5 - 5分钟）。释放出的萘啶酸和萘啶酸衍生物对大肠杆菌、金黄色葡萄球菌和伤寒沙门氏菌具有抗菌特性，持续时间超过3个月。这项研究表明，通过长时间（超过1个月）递送抗生素，将这种新型聚合物应用于制造抗导管引发感染的引流导管具有可能性。
