Nyska Meir, Shabat Shay, Long Philip H, Howard Charles, Ezov Nathan, Levin-Harrus Tal, Mittelman Moshe, Redlich Meir, Yedgar Saul, Nyska Abraham
Department of Orthopaedic Surgery, Sapir Medical Center, 48 Tchernichovsky Street, Kfar-Saba 44281, Israel.
J Pediatr Orthop. 2005 May-Jun;25(3):346-50. doi: 10.1097/01.bpo.0000153878.28185.2a.
Exposure of rats to 2-butoxyethanol (BE) produces early hemolytic anemia and disseminated thrombosis. This leads to infarctions in multiple organs, including bones and cartilage. BE, administered for different durations of exposure in two separate experiments, produced metaphyseal vascular thrombosis, growth plate infarction, and partial or complete physeal growth arrest. This reproducible model may serve as a useful tool in the study of some conditions that manifest growth plate damage. The suitability of this model for investigating the pathogenesis of growth plate necrosis and as a model for potential therapy for various human growth plate disorders are discussed.
将大鼠暴露于2-丁氧基乙醇（BE）会导致早期溶血性贫血和弥散性血栓形成。这会导致包括骨骼和软骨在内的多个器官发生梗死。在两项独立实验中，给予大鼠不同暴露时长的BE，均导致干骺端血管血栓形成、生长板梗死以及部分或完全的骺板生长停滞。这个可重复的模型可能是研究某些表现为生长板损伤的病症的有用工具。本文讨论了该模型在研究生长板坏死发病机制方面的适用性，以及作为各种人类生长板疾病潜在治疗模型的适用性。
