含有2,2'-联吡啶和芳基重氮-β-二酮辅助配体的混合配体钌（II）配合物：合成、物理化学研究及抗肿瘤性质

Mixed-ligand Ru(II) complexes with 2,2'-bipyridine and aryldiazo-beta-diketonato auxillary ligands: synthesis, physico-chemical study and antitumour properties.

作者信息

Mishra Lallan, Yadaw Ajay K, Bhattacharya Subrato, Dubey Santosh K

机构信息

Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India.

出版信息

J Inorg Biochem. 2005 May;99(5):1113-8. doi: 10.1016/j.jinorgbio.2005.02.003.

DOI:10.1016/j.jinorgbio.2005.02.003

PMID:15833334

Abstract

The complexes of Ru(II)-2,2'-bipyridyl with substituted diazopentane-2,4-diones (L1H-L5H) were synthesized and characterized by elemental analyses, conductance, FAB (fast atom bombardment) mass and spectral (IR, UV/Vis (UV/visible), NMR) studies. Molecular geometry optimization of the complexes was also made. None of the complexes luminesce. However, facilitated oxidation of Ru(II) to Ru(III) was evidenced from their lower reduction potential data. The ligands and their complexes were tested for their antitumour activity against a variety of tumour cell lines. Though activity is found to vary with the type of tumour cell lines used, yet complex 5 with naphtyldiazopentane-2,4-dione as co-ligand was found to be a potential compound as it showed in general significant activity against all cell lines studied.

摘要

合成了钌（II）-2,2'-联吡啶与取代重氮戊烷-2,4-二酮（L1H-L5H）的配合物，并通过元素分析、电导率、快原子轰击质谱以及光谱（红外、紫外/可见、核磁共振）研究对其进行了表征。还对配合物的分子几何结构进行了优化。这些配合物均不发光。然而，从其较低的还原电位数据可以证明钌（II）向钌（III）的氧化过程较为容易。测试了这些配体及其配合物对多种肿瘤细胞系的抗肿瘤活性。尽管发现活性会因所使用的肿瘤细胞系类型而有所不同，但以萘基重氮戊烷-2,4-二酮作为共配体的配合物5被发现是一种潜在的化合物，因为总体而言它对所有研究的细胞系都表现出显著的活性。