Zayat Leonardo, Salierno Marcelo, Etchenique Roberto
Departamento de Química Inorgánica, Analítica y Química Física, INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pabellón 2, Argentina.
Inorg Chem. 2006 Feb 20;45(4):1728-31. doi: 10.1021/ic0512983.
The synthesis and characterization of a series of ruthenium bis(bipyridine) complexes where the inorganic moiety acts as a photolabile protecting group is described. Complexes of the type [Ru(bpy)2L2]+ where bpy = 2,2'-bipyridine and L = butylamine, gamma-aminobutyric acid, tyramine, tryptamine, and serotonin were studied by nuclear magnetic resonance, cyclic voltammetry, and electronic absorption spectroscopy. In all cases, ligands are coordinated by the amine group. The complexes are stable in water for several days and deliver one molecule of ligand upon irradiation with visible light (450 nm). These properties make them suitable for their use as biological caged compounds.
描述了一系列钌双（联吡啶）配合物的合成与表征，其中无机部分作为光不稳定保护基团。研究了[Ru(bpy)₂L₂]⁺类型的配合物，其中bpy = 2,2'-联吡啶，L = 丁胺、γ-氨基丁酸、酪胺、色胺和血清素，采用核磁共振、循环伏安法和电子吸收光谱进行研究。在所有情况下，配体均通过胺基配位。这些配合物在水中稳定数天，并在可见光（450 nm）照射下释放一分子配体。这些特性使其适合用作生物笼形化合物。
