Stefanski Volker, Raabe Claudia, Schulte Marcus
Department of Animal Physiology, University of Bayreuth, Universitätsstrasse 30, D-95440 Bayreuth, Germany.
J Neuroimmunol. 2005 May;162(1-2):81-8. doi: 10.1016/j.jneuroim.2005.01.011.
The consequences of pregnancy and social stress on blood immune cells and on plasma corticosterone concentrations were assessed in Long Evans rats. Normal pregnancy in control females was characterized by a progressive increase in corticosterone concentration and increasing numbers of granulocytes. In contrast, CD4 T, CD8 T, and B cell numbers as well as the proliferative response of lymphocytes decreased as pregnancy progressed. Stress was induced in pregnant females by social confrontation for 2 h daily with a female resident opponent over a period of 2 months. Corticosterone concentrations were substantially higher in pregnant stressed than in pregnant control rats. Furthermore, the numbers of monocytes, NK and B cells were lower in stressed females, and there was a strong trend towards suppressed lymphocyte proliferation. Interestingly, pregnant females did not show granulocytosis in response to the stressor. In sum, the social stress paradigm in females appears to be a good model for the investigation of the interactions between stress, pregnancy and the immune system. It also provides an excellent platform for studies on prenatal stress under relatively naturalistic conditions.
在长 Evans 大鼠中评估了怀孕和社会压力对血液免疫细胞及血浆皮质酮浓度的影响。对照雌性大鼠的正常怀孕表现为皮质酮浓度逐渐升高以及粒细胞数量增加。相比之下，随着怀孕进程，CD4 T 细胞、CD8 T 细胞和 B 细胞数量以及淋巴细胞的增殖反应均下降。通过在 2 个月的时间里每天与一只雌性常驻对手进行 2 小时的社会对抗，对怀孕雌性大鼠施加压力。怀孕应激大鼠的皮质酮浓度显著高于怀孕对照大鼠。此外，应激雌性大鼠的单核细胞、NK 细胞和 B 细胞数量较低，并且淋巴细胞增殖受到抑制的趋势明显。有趣的是，怀孕雌性大鼠对压力源没有表现出粒细胞增多。总之，雌性大鼠的社会压力范式似乎是研究压力、怀孕和免疫系统之间相互作用的良好模型。它还为在相对自然的条件下研究产前压力提供了一个极好的平台。
