Götz Alexander A, Wittlinger Sabrina, Stefanski Volker
Department of Animal Physiology, University of Bayreuth, Universitätsstrasse 30, D-95440 Bayreuth, Germany.
J Neuroimmunol. 2007 Apr;185(1-2):95-102. doi: 10.1016/j.jneuroim.2007.01.019. Epub 2007 Mar 9.
The impact of social confrontations on distribution and function of blood immune cells in adult male rat offspring from stressed and non-stressed pregnancies was studied. Repeated 2 h resident-intruder confrontations were performed on ten consecutive days using a protective cage. Prenatally stressed intruder males (PSI) had a generally lower number of neutrophiles, monocytes, T and NK cells and reduced lymphocyte proliferation in whole blood cultures than prenatally non-stressed control intruders (PCI). Differences also existed in the temporal dynamics of immunological changes. On confrontation day 1, stress-induced reductions in lymphocyte and monocyte numbers but increased granulocyte counts were observed in both groups. However, only PCI showed a partial recovery of T cell and monocyte numbers on confrontation day 10 and a full restoration in all immune cell numbers 5 days post-confrontation. Thus, the immunological response to a psychosocial stressor in adult rats can be modified by the mothers' exposure to stress during pregnancy.
研究了社会对抗对来自应激和非应激妊娠的成年雄性大鼠后代血液免疫细胞分布和功能的影响。使用保护笼连续十天每天进行2小时的常驻-入侵者对抗。与产前非应激对照入侵者（PCI）相比，产前应激入侵者雄性（PSI）的嗜中性粒细胞、单核细胞、T细胞和NK细胞数量通常较低，全血培养中的淋巴细胞增殖减少。免疫变化的时间动态也存在差异。在对抗第1天，两组均观察到应激诱导的淋巴细胞和单核细胞数量减少，但粒细胞计数增加。然而，只有PCI在对抗第10天显示T细胞和单核细胞数量部分恢复，在对抗后5天所有免疫细胞数量完全恢复。因此，成年大鼠对心理社会应激源的免疫反应可因母亲在孕期暴露于应激而改变。
