Bleustein Clifford B, Fogarty James D, Eckholdt Haftan, Arezzo Joseph C, Melman Arnold
Urology Specialty Care, Englewood Cliffs, New Jersey, USA.
Urology. 2005 Apr;65(4):773-7. doi: 10.1016/j.urology.2004.11.007.
To evaluate penile sensory thresholds in neonatally circumcised and uncircumcised men.
We evaluated 125 patients, 62 uncircumcised men and 63 neonatally circumcised men. All patients completed the Erectile Function domain of the International Index of Erectile Function questionnaire. Of the 125 patients, 29 (International Index of Erectile Function score of between 25 and 30) were placed in the functional group, and 96 in the dysfunctional group. The patients were tested on the dorsal midline glans of the penis (foreskin retracted). Quantitative somatosensory testing was performed and included vibration, pressure, spatial perception, and warm and cold thermal thresholds.
In the functional group, t-test analysis demonstrated a significant (P <0.001) difference, with worse vibration and better pressure sensation for uncircumcised men. When controlling for age, hypertension, and diabetes, all t-test significance was lost. In the dysfunctional group, circumcised men (49 +/- 16 years) were significantly younger (P <0.01) than uncircumcised men (56 +/- 13 years). For the dysfunctional group, t-test analysis also demonstrated worse vibration sensation for uncircumcised men (P <0.01). Again, when controlling for age, hypertension, and diabetes, all t-test significance was lost.
We present a comparative analysis of uncircumcised and circumcised men using a battery of quantitative somatosensory tests that evaluate the spectrum of small to large axon nerve fiber function. Our study controlled for factors, including age, erectile function status, diabetes, and hypertension, that have been shown to alter neurologic testing. In our study of neonatally circumcised men, we demonstrated that circumcision status does not significantly alter the quantitative somatosensory testing results at the glans penis.
评估新生儿期接受包皮环切术和未接受包皮环切术男性的阴茎感觉阈值。
我们评估了125名患者，其中62名未接受包皮环切术的男性和63名新生儿期接受包皮环切术的男性。所有患者均完成了国际勃起功能指数问卷中的勃起功能领域部分。在这125名患者中，29名（国际勃起功能指数得分在25至30之间）被归入功能组，96名被归入功能障碍组。对患者阴茎背侧中线龟头（包皮回缩）进行测试。进行了定量体感测试，包括振动、压力、空间感知以及温热和冷觉阈值测试。
在功能组中，t检验分析显示存在显著差异（P<0.001），未接受包皮环切术的男性振动感觉较差而压力感觉较好。在控制年龄、高血压和糖尿病因素后，所有t检验的显著性均消失。在功能障碍组中，接受包皮环切术的男性（49±16岁）比未接受包皮环切术的男性（56±13岁）显著年轻（P<0.01）。对于功能障碍组，t检验分析也显示未接受包皮环切术的男性振动感觉较差（P<0.01）。同样，在控制年龄、高血压和糖尿病因素后，所有t检验的显著性均消失。
我们使用一系列评估小至大轴突神经纤维功能范围的定量体感测试，对未接受包皮环切术和接受包皮环切术的男性进行了比较分析。我们的研究控制了包括年龄、勃起功能状态、糖尿病和高血压等已被证明会改变神经学测试结果的因素。在我们对新生儿期接受包皮环切术男性的研究中，我们证明包皮环切状态不会显著改变阴茎龟头的定量体感测试结果。
