SV40增加了接触石棉人群患恶性间皮瘤的风险：一项分子流行病学病例对照研究。
SV40 enhances the risk of malignant mesothelioma among people exposed to asbestos: a molecular epidemiologic case-control study.
作者信息
Cristaudo Alfonso, Foddis Rudy, Vivaldi Agnese, Buselli Rodolfo, Gattini Vittorio, Guglielmi Giovanni, Cosentino Francesca, Ottenga Franco, Ciancia Eugenio, Libener Roberta, Filiberti Rosangela, Neri Monica, Betta Piergiacomo, Tognon Mauro, Mutti Luciano, Puntoni Riccardo
机构信息
Department of Endocrinology and Metabolism, Orthopedic and Traumatology, Occupational Medicine, University of Pisa, 56100 Pisa, Italy.
出版信息
Cancer Res. 2005 Apr 15;65(8):3049-52. doi: 10.1158/0008-5472.CAN-04-2219.
We conducted a case-control study on asbestos exposure and presence of SV40 in tumor samples of malignant mesotheliomas (MMs) and bladder urotheliomas (BUs). PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MMs and 6 (33.3%) BUs. The odds ratio for MM Asb- and SV40+ was 0.4 [95% confidence interval (95% CI), 0.03-4.0], for Asb+ and SV40- was 3.6 (95% CI, 0.6-21.0), and for Asb+ and SV40+ was 12.6 (95% CI, 1.2-133.9). Our results suggest that SV40 increases the risk of MM among individuals exposed to asbestos.
我们针对恶性间皮瘤（MMs）和膀胱尿路上皮癌（BUs）肿瘤样本中的石棉暴露情况及SV40的存在进行了一项病例对照研究。聚合酶链反应（PCR）分析显示，8例（42.1%）MMs和6例（33.3%）BUs中存在SV40 DNA（SV40阳性）。MM中石棉暴露阴性且SV40阳性的优势比为0.4[95%置信区间（95%CI），0.03 - 4.0]，石棉暴露阳性且SV40阴性的优势比为3.6（95%CI，0.6 - 21.0），石棉暴露阳性且SV40阳性的优势比为12.6（95%CI，1.2 - 133.9）。我们的结果表明，SV40会增加石棉暴露个体患MM的风险。
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