Kawai M, Maeda O, Iwata M, Oguchi H, Kojima M, Kikkawa F, Tomoda Y
Department of Obstetrics and Gynecology, Nagoya University School of Medicine.
Rinsho Byori. 1992 Feb;40(2):146-51.
Ovarian carcinoma is a silent disease with few symptoms. Early detection of ovarian cancer is difficult. Transvaginal Doppler ultrasound with color flow imaging is a new technique in the evaluation of gynecological diseases. This method was used in the diagnosis of ovarian tumors in 39 women who were treated in the Department of Obstetrics and Gynecology, Nagoya University Hospital. Wave forms of the parenchymal tumor arteries or tumor surface arteries were compared by according to the pulsatility index (PI). 1/PI was 0.69 +/- 0.04 in benign tumor and 2.33 +/- 1.36 in malignant tumors (p less than 0.01). When the cutoff value of 1/PI was set at 0.8 (cutoff value of PI: 1.25), the accuracy of diagnosis was 84.6% (33/39). The accuracy of ultrasonographic pattern classification and CA125 were 74.4% (29/39) and 53.8% (21/39), respectively. In 18 tumors with low CA125 (less than 35 U/ml), 5 of 7 malignant tumors (71.4%) had high 1/PI (greater than 0.8), and benign tumor, low 1/PI (less than 0.8) or non-detectable wave forms. This procedure should prove to be useful in the diagnosis of ovarian cancer.
卵巢癌是一种症状隐匿的疾病。早期发现卵巢癌很困难。经阴道彩色多普勒超声成像技术是评估妇科疾病的一项新技术。该方法用于名古屋大学医院妇产科收治的39例卵巢肿瘤患者的诊断。根据搏动指数（PI）比较实质肿瘤动脉或肿瘤表面动脉的波形。良性肿瘤的1/PI为0.69±0.04，恶性肿瘤为2.33±1.36（P＜0.01）。当1/PI的临界值设定为0.8（PI临界值：1.25）时，诊断准确率为84.6%（33/39）。超声图像分类和CA125的诊断准确率分别为74.4%（29/39）和53.8%（21/39）。在18例CA125水平低（＜35 U/ml）的肿瘤中，7例恶性肿瘤中有5例（71.4%）的1/PI较高（＞0.8），良性肿瘤的1/PI较低（＜0.8）或未检测到波形。该方法在卵巢癌诊断中应是有用的。
