Kaneda T, Hidaka Y, Kashiwai T, Tada H, Takano T, Nishiyama S, Amino N, Miyai K
Department of Laboratory of Medicine, Osaka University School of Medicine.
Rinsho Byori. 1992 Feb;40(2):179-81.
Coix seed has been used in patients with verruca vulgaris and verruca planae juveniles, which have been considered to be induced by viral infection. Moreover, coixenolide, component in the seeds of coix, was reported to show anti-tumor activity. Possibly coix seed may have some influence on the cytotoxic activity of peripheral lymphocytes but there has been no data on this. Then we investigated the changes in number of cytotoxic lymphoid cells in seven volunteers before, during (four weeks) and after taking six coix seed tablets. Lymphocyte subsets were analyzed with monoclonal antibodies using a flow cytometer. The level of CD3+CD56+ (MHC-non restricted cytotoxic T cells) markedly increased at four weeks (before 1.9 +/- 0.5% vs four weeks 4.2 +/- 0.7%, p less than 0.01). The level of CD16+CD57- (the mature, most active natural killer cells) increased at three weeks (before 4.5 +/- 0.8% vs three weeks 5.2 +/- 0.8%, p less than 0.05). The level of CD3-CD56+ (natural killer cells) and the level of CD16+CD57+ (the variable active natural killer cells) decreased at one week and returned to normal level thereafter (before 13.7 +/- 2.1% vs one week 11.2 +/- 1.5%, p less than 0.05; before 8.8 +/- 1.5% vs one week 6.9 +/- 1.3%, p less than 0.05, respectively). These results indicate that coix seed modulate the peripheral blood lymphocyte subsets and may be effective to virus disease through the enhancement of cytotoxic activity.
薏苡仁已被用于治疗寻常疣和扁平疣患者，这些疾病被认为是由病毒感染引起的。此外，据报道，薏苡仁种子中的成分薏苡仁酯具有抗肿瘤活性。薏苡仁可能对外周淋巴细胞的细胞毒活性有一定影响，但目前尚无相关数据。然后，我们调查了7名志愿者在服用6片薏苡仁片之前、期间（四周）和之后细胞毒性淋巴细胞数量的变化。使用流式细胞仪用单克隆抗体分析淋巴细胞亚群。CD3 + CD56 +（MHC非限制性细胞毒性T细胞）水平在四周时显著升高（服药前为1.9±0.5%，四周时为4.2±0.7%，p＜0.01）。CD16 + CD57 -（成熟、最活跃的自然杀伤细胞）水平在三周时升高（服药前为4.5±0.8%，三周时为5.2±0.8%，p＜0.05）。CD3 - CD56 +（自然杀伤细胞）水平和CD16 + CD57 +（可变活性自然杀伤细胞）水平在一周时下降，此后恢复到正常水平（服药前分别为13.7±2.1%和8.8±1.5%，一周时分别为11.2±1.5%和6.9±1.3%，p均＜0.05）。这些结果表明，薏苡仁可调节外周血淋巴细胞亚群，并可能通过增强细胞毒活性对病毒疾病有效。
