National Institute of Cancer Research, National Health Research Institutes, Tainan; ; Institute of Clinical Pharmacy and Pharmaceutical Sciences, National Cheng Kung University Medical College, Tainan;
National Institute of Cancer Research, National Health Research Institutes, Tainan;
J Tradit Complement Med. 2012 Oct;2(4):267-75. doi: 10.1016/s2225-4110(16)30112-2.
Adlay ( yì yĭ "soft-shelled job's tears", the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf) is a grass crop that has long been used in traditional Chinese medicine (TCM) and as a nourishing food in China for the treatment of warts, chapped skin, rheumatism, neuralgia, inflammatory, and neoplastic diseases. In addition, adlay also has been said to have stomachic, diuretic, antipholgistic, anodynic, and antispasmodic effects. Carcinogenesis is a multistage process that begins with exposure of viruses or chemicals that are found in the environment. Chemoprevention refers to the use of natural or synthetic, non-toxic chemical substances to reverse, repress, or prevent carcinogenesis. In this review, we summarize recent research attempting to study the chemopreventive blocking and suppressing potential of adlay and its active components in scavenging electrophiles and reactive oxygen species, antimutagenicity, enhancing Nrf2-mediated detoxification and antioxidant effect, altering carcinogen metabolism, suppressing proliferation, decreasing inflammation, and enhancing antitumor immunity. In addition, several active components with diverse chemopreventive properties have been also mentioned in this review article.
薏苡（yì yĭ“软壳珍珠”，薏苡仁的种子 Coix lachryma-jobi L. var. ma-yuen Stapf）是一种草本作物，在中国长期以来一直被用于传统中药（TCM）和滋补食品，用于治疗疣、皲裂皮肤、风湿、神经痛、炎症和肿瘤疾病。此外，薏苡据说还有健胃、利尿、解热、止痛和抗痉挛的作用。癌变是一个多阶段的过程，始于暴露于环境中发现的病毒或化学物质。化学预防是指使用天然或合成的、无毒的化学物质来逆转、抑制或预防癌变。在这篇综述中，我们总结了最近的研究，试图研究薏苡及其活性成分在清除亲电体和活性氧、抗诱变、增强 Nrf2 介导的解毒和抗氧化作用、改变致癌物代谢、抑制增殖、减少炎症和增强抗肿瘤免疫方面的化学预防阻断和抑制潜力。此外，本文还提到了几种具有不同化学预防特性的活性成分。
