Lenfant M, di Giusto L, Oleson D L, Garcia-Giralt E, Mayadoux E, Villanueva V, Adlakha R C
Biomedicine. 1979 Jul;31(4):110-3.
Spermine, spermidine and a purified spleen extract (PSE) have been compared in vivo in these three tests: hemolytic plaque forming capacity in sensitized mice, delayed hypersensitivity reaction and 3H-thymidine incorporation into various tissue cells. The results obtained demonstrated that the immunosuppressive activity of PSE cannot be attributed to those polyamines. Ion exchange analysis of PSE before and after acid hydrolysis confirmed the absence of free and/or bound polyamines in the studied extract.
在这三项试验中对精胺、亚精胺和一种纯化的脾脏提取物（PSE）进行了体内比较：致敏小鼠的溶血空斑形成能力、迟发型超敏反应以及3H-胸腺嘧啶核苷掺入各种组织细胞。所获得的结果表明，PSE的免疫抑制活性不能归因于那些多胺。对酸水解前后的PSE进行离子交换分析，证实所研究的提取物中不存在游离和/或结合的多胺。
