Kumar Perikala V, Monabati Ahmad, Tabei Seyed Z, Ramzy Mani, Husseini Syed Vahid, Khajeh Fatemeh
Department of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Acta Cytol. 2005 Mar-Apr;49(2):177-80. doi: 10.1159/000326129.
Follicular thyroid carcinomas (FTCs) usually have a benign clinical course, with an excellent long-term prognosis and a propensity for vascular invasion. The most common sites of metastases are lung and bone. Only a few reports are available on fine needle aspiration biopsy findings from metastatic lesions of FTC.
A 68-year-old man presented with a thyroid mass and skin nodule on the scalp. Skin nodule aspiration revealed metastatic FTC. A 52-year-old woman and 60-year-old man were investigated for chronic anemia. As part of the routine investigation, bone marrow aspiration and biopsy were performed from the posterior iliac crest and diagnosed as metastatic FTC. Further questioning revealed that the patients had undergone thyroidectomy 10 and 13 years earlier. The aspiration material in all 3 cases revealed epithelial cell clusters with marginal (fire-flare) vacuoles.
Cytologic diagnosis of metastatic FTC has been reported rarely. Marginal (fire-flare) vacuoles aid in making the diagnosis of metastatic FTC.
滤泡状甲状腺癌（FTC）通常具有良性的临床病程，长期预后良好，且有血管侵犯倾向。最常见的转移部位是肺和骨。关于FTC转移灶细针穿刺活检结果的报道较少。
一名68岁男性，头皮出现甲状腺肿块和皮肤结节。皮肤结节穿刺显示为FTC转移。一名52岁女性和一名60岁男性因慢性贫血接受检查。作为常规检查的一部分，从髂后嵴进行骨髓穿刺和活检，诊断为FTC转移。进一步询问发现，这两名患者分别在10年前和13年前接受过甲状腺切除术。所有3例患者的穿刺材料均显示有边缘（火焰状）空泡的上皮细胞簇。
关于FTC转移的细胞学诊断报道很少。边缘（火焰状）空泡有助于FTC转移的诊断。
