O'Connell Fionnuala, Cibas Edmund S
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Acta Cytol. 2005 Mar-Apr;49(2):187-90. doi: 10.1159/000326131.
Ciliation is a normal finding in the endometrium, fallopian tubes and cervix. Because cilia are characteristically lost when malignant tumors arise at these sites, the detection of cilia on light microscopy is frequently used to support a benign diagnosis. Ciliated carcinomas of müllerian duct origin, however, do occur, albeit rarely, and can pose a potential diagnostic difficulty in cytologic specimens.
A woman with a histologically confirmed ciliated adenocarcinoma of the cervix had prior liquid-based cervical cytology showing atypical, ciliated glandular cells that initially raised the diagnostic consideration of tubal metaplasia. A concurrent biopsy, however, revealed focally ciliated adenocarcinoma of the cervix.
Awareness of the ciliated variant of adenocarcinoma of the cervix is important to avoid overreliance on ciliation as a definitive feature of benignity in cervical cytologic specimens.
纤毛在子宫内膜、输卵管和宫颈中是一种正常表现。由于当这些部位发生恶性肿瘤时纤毛通常会消失，因此在光学显微镜下检测到纤毛常被用于支持良性诊断。然而，苗勒管起源的纤毛癌确实会发生，尽管很少见，并且在细胞学标本中可能会造成潜在的诊断困难。
一名组织学确诊为宫颈纤毛腺癌的女性，之前的液基宫颈细胞学检查显示有非典型的、有纤毛的腺细胞，最初引起了输卵管化生的诊断考虑。然而，同时进行的活检显示为宫颈局灶性纤毛腺癌。
认识宫颈腺癌的纤毛变异型对于避免在宫颈细胞学标本中过度依赖纤毛作为良性的决定性特征很重要。
