Jun Young-Wook, Huh Yong-Min, Choi Jin-Sil, Lee Jae-Hyun, Song Ho-Taek, Kim Sungjun, Yoon Sarah, Kim Kyung-Sup, Shin Jeon-Soo, Suh Jin-Suck, Cheon Jinwoo
Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
J Am Chem Soc. 2005 Apr 27;127(16):5732-3. doi: 10.1021/ja0422155.
Since the use of magnetic nanocrystals as probes for biomedical system is attractive, it is important to develop optimal synthetic protocols for high-quality magnetic nanocrystals and to have the systematic understanding of their nanoscale properties. Here we present the development of a synthetically controlled magnetic nanocrystal model system that correlates the nanoscale tunabilities in terms of size, magnetism, and induced nuclear spin relaxation processes. This system further led to the development of high-performance nanocrystal-antibody probe systems for the diagnosis of breast cancer cells via magnetic resonance imaging.
由于将磁性纳米晶体用作生物医学系统的探针很有吸引力，因此开发高质量磁性纳米晶体的最佳合成方案并对其纳米级特性有系统的了解非常重要。在此，我们展示了一种合成可控的磁性纳米晶体模型系统的开发，该系统在尺寸、磁性和诱导核自旋弛豫过程方面关联了纳米级可调性。该系统进一步促成了用于通过磁共振成像诊断乳腺癌细胞的高性能纳米晶体 - 抗体探针系统的开发。
