氨基酸功能化磁铁矿纳米颗粒 FeO@AA（AA = Ser、Cys、Pro、Trp）作为具有潜在治疗应用的生物相容性磁铁矿纳米颗粒。
Aminoacid functionalised magnetite nanoparticles FeO@AA (AA = Ser, Cys, Pro, Trp) as biocompatible magnetite nanoparticles with potential therapeutic applications.
机构信息
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, 1-7 Gh Polizu Street, 011061, Bucharest, Romania.
National Centre for Micro and Nanomaterials and National Centre for Food Safety, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, Spl. Independentei 313, 060042, Bucharest, Romania.
出版信息
Sci Rep. 2024 Oct 31;14(1):26228. doi: 10.1038/s41598-024-76552-1.
Magnetic nanoparticles (MNPs) are of great interest for their wide applications in biomedical applications, such as bioimaging, antitumoral therapies, regenerative medicine, and drug delivery. The work aimed to obtain biocompatible magnetite nanoparticles coated with amino acids of the general formula FeO@AA (AA = L-tryptophan, L-serine, L-proline and L-cysteine) for potential therapeutic application in anticancer drug delivery. The obtained materials were characterised using XRD, FTIR, DLS analysis, SEM, thermogravimetry (TG), differential scanning calorimetry (DSC), and UV-vis spectroscopy. The photocatalytic, cytotoxic and antimicrobial activity tests of the obtained materials were carried out. The choice of amino acid determines the properties of the material and its future use, for example, FeO@Cys supports radical production, which may increase the efficiency of catalytic degradation, while tryptophan captures radicals, which may be an advantage in several biomedical applications. FeO@Trp exhibited good antimicrobial activity (MBEC and MIC) against E. coli ATCC 25922, P. aeruginosa ATCC 27853 and C. albicans ATCC 10231 while FeO@Pro exhibited the best results against S. aureus ATCC 25923.
磁性纳米粒子（MNPs）因其在生物医学应用中的广泛应用而备受关注，例如生物成像、抗肿瘤治疗、再生医学和药物输送。本工作旨在获得具有生物相容性的磁性纳米粒子，其表面包覆有通式为 FeO@AA（AA = L-色氨酸、L-丝氨酸、L-脯氨酸和 L-半胱氨酸）的氨基酸，用于潜在的抗癌药物输送治疗应用。所获得的材料采用 XRD、FTIR、DLS 分析、SEM、热重分析（TG）、差示扫描量热法（DSC）和 UV-vis 光谱进行表征。对所获得的材料进行了光催化、细胞毒性和抗菌活性测试。氨基酸的选择决定了材料的性质及其未来的用途，例如，FeO@Cys 支持自由基的产生，这可能会提高催化降解的效率，而色氨酸捕获自由基，这可能是在几种生物医学应用中的优势。FeO@Trp 对大肠杆菌 ATCC 25922、铜绿假单胞菌 ATCC 27853 和白色念珠菌 ATCC 10231 表现出良好的抗菌活性（MBEC 和 MIC），而 FeO@Pro 对金黄色葡萄球菌 ATCC 25923 的抑制效果最好。
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