Chen Zheng-qiong, Cheng Ya, Su Hong-yuan, Xie Rong-kai, Lin Gui-lan, Wang Zhi, Chen Bo-jie
Department of Obstetrics and Gynecology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Zhonghua Fu Chan Ke Za Zhi. 2005 Mar;40(3):164-7.
To investigate whether maternal serum leptin level can be used as a predictor of gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (GIGT).
Five hundred and eighty-three pregnant women were screened for GDM by the 50g oral glucose challenge test. At the same time, serum leptin levels were determined by radioimmunoassay, then the relationship between maternal serum leptin level and the incidence of GIGT and GDM was analyzed. According to the screening result, all the pregnant women were divided into three groups, the normal glucose group (NGT group), the gestational impaired glucose tolerance group (GIGT group), and gestational diabetes mellitus group (GDM group). GIGT group and GDM group were named as glucose intolerant group as a whole.
(1) The serum leptin concentration of normal pregnant women ascended gradually from (7.0 +/- 1.8) microg/L in 24 gestational week to (9.4 +/- 2.1) microg/L during 34 - 36 gestational week, and then declined slightly but still maintained high level till delivery. (2) The serum leptin concentration of the glucose intolerant pregnant women ranged from (11.3 +/- 3.1) microg/L to(14.5 +/- 4.3) microg/L, and showed no difference among different gestational weeks (P > 0.05). (3) Serum leptin level of glucose intolerant women was (12.5 +/- 3.5) microg/L on average, much higher than that of NGT group, (8.5 +/- 2.6) microg/L (P < 0.05), and this difference remained in any gestational week (P < 0.05). (4) Most of the GDM clustered in the higher leptin level groups and 66.7% GDM had a serum leptin level higher than 14.0 microg/L. Moreover, 64.7% of women whose serum leptin level was above 17.0 microg/L had different degree of glucose intolerance. Serum leptin level positively correlated with the incidence of GIGT and GDM.
Serum leptin level is correlated with glucose tolerance during pregnancy. Its abnormal increase during pregnancy might have a predictive value for GDM and GIGT.
探讨孕妇血清瘦素水平是否可作为妊娠期糖尿病（GDM）和妊娠期糖耐量受损（GIGT）的预测指标。
采用50g口服葡萄糖耐量试验对583例孕妇进行GDM筛查。同时，采用放射免疫法测定血清瘦素水平，分析孕妇血清瘦素水平与GIGT和GDM发生率的关系。根据筛查结果，将所有孕妇分为三组，即血糖正常组（NGT组）、妊娠期糖耐量受损组（GIGT组）和妊娠期糖尿病组（GDM组）。GIGT组和GDM组统称为糖耐量异常组。
（1）正常孕妇血清瘦素浓度从孕24周时的（7.0±1.8）μg/L逐渐升高至孕34 - 36周时的（9.4±2.1）μg/L，随后略有下降，但直至分娩仍维持在较高水平。（2）糖耐量异常孕妇血清瘦素浓度在（11.3±3.1）μg/L至（14.5±4.3）μg/L之间，不同孕周间差异无统计学意义（P>0.05）。（3）糖耐量异常孕妇血清瘦素水平平均为（12.5±3.5）μg/L，显著高于NGT组的（8.5±2.6）μg/L（P<0.05），且在任何孕周均存在此差异（P<0.05）。（4）大多数GDM患者集中在瘦素水平较高的组，66.7%的GDM患者血清瘦素水平高于14.0μg/L。此外，血清瘦素水平高于17.0μg/L的孕妇中，64.7%有不同程度的糖耐量异常。血清瘦素水平与GIGT和GDM的发生率呈正相关。
血清瘦素水平与孕期糖耐量相关。孕期血清瘦素水平异常升高可能对GDM和GIGT具有预测价值。
