Ma Shui-qing, Bai Chun-mei, Yu Xiao-hong, An Yun-ting, Lang Jing-he
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing.
Zhonghua Fu Chan Ke Za Zhi. 2005 Mar;40(3):183-5.
To investigate the clinical and pathological characteristics of primary cervical malignant melanoma, the treatment, and prognosis.
The clinical and pathological data of four patients with primary malignant melanoma of the cervix admitted to our hospital from Sept. 1996 to Aug 2002 were analyzed retrospectively. Their follow-up records were also reviewed. Nerve tissue protein S-100 and monoclonal antibody to melanoma (HMB-45) were examined in all cases by immunohistochemical method.
All the patients received radical hysterectomy. In addition, three of them received chemotherapy, and one received immunotherapy simultaneously. One patient died six months and another 41 months after the operation respectively. One patient survived for 3 years, and another over 6 years free of tumor. S-100 protein and HMB-45 were positive in all patients.
The prognosis of primary malignant melanoma of cervix is relatively poor. S-100 protein and HMB-45 play important roles in the diagnosis of primary malignant melanoma of cervix. Radical hysterectomy, chemotherapy combined with dimethyl triazemo imidazole carboxamide (DTIC) and immunotherapy can improve the prognosis if the disease could be diagnosed in early stage.
探讨原发性宫颈恶性黑色素瘤的临床及病理特征、治疗方法及预后情况。
回顾性分析1996年9月至2002年8月我院收治的4例原发性宫颈恶性黑色素瘤患者的临床及病理资料，并查阅其随访记录。所有病例均采用免疫组织化学方法检测神经组织蛋白S-100和黑色素瘤单克隆抗体（HMB-45）。
所有患者均接受了根治性子宫切除术。此外，其中3例接受了化疗，1例同时接受了免疫治疗。1例患者术后6个月死亡，另1例术后41个月死亡。1例患者存活3年，另1例无瘤生存超过6年。所有患者S-100蛋白和HMB-45均呈阳性。
原发性宫颈恶性黑色素瘤预后相对较差。S-100蛋白和HMB-45在原发性宫颈恶性黑色素瘤的诊断中起重要作用。如果能早期诊断，根治性子宫切除术、联合氮烯咪胺（DTIC）化疗及免疫治疗可改善预后。
