时机决定一切：细胞周期调控在不对称分裂中的作用。

When timing is everything: role of cell cycle regulation in asymmetric division.

作者信息

Prokopenko Sergei N, Chia William

机构信息

Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore 117604, Singapore.

出版信息

Semin Cell Dev Biol. 2005 Jun;16(3):423-37. doi: 10.1016/j.semcdb.2005.02.005.

DOI:10.1016/j.semcdb.2005.02.005

PMID:15840450

Abstract

Asymmetric division is a fundamental mechanism of generating cell diversity during development. One of its hallmarks is asymmetric localization during mitosis of proteins that specify daughter cell fate. Studies in Drosophila show that subcellular localization of many proteins required for asymmetric division of neuronal progenitors correlates with progression through mitosis. Yet, how cell cycle and asymmetric division machineries cooperate remains unclear. Recent data show that (1) key cell cycle regulators are required for asymmetric localization of cell fate determinants and for cell fate determination and (2) molecules that mediate asymmetric division can also act to modulate proliferation potential of progenitor cells.

摘要

不对称分裂是发育过程中产生细胞多样性的基本机制。其特征之一是在有丝分裂期间指定子细胞命运的蛋白质的不对称定位。果蝇研究表明，神经元祖细胞不对称分裂所需的许多蛋白质的亚细胞定位与有丝分裂进程相关。然而，细胞周期和不对称分裂机制如何协同仍不清楚。最近的数据表明：（1）关键细胞周期调节因子对于细胞命运决定因子的不对称定位以及细胞命运决定是必需的；（2）介导不对称分裂的分子也可调节祖细胞的增殖潜能。