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[多种N-取代哌嗪衍生物对大鼠乌头碱所致心律失常的影响]

[Cardiac anti-arrhythmic effect of various N-substituted piperazine derivatives with respect to aconitine in the rat].

作者信息

Scotto-DiTella A M

出版信息

C R Seances Soc Biol Fil. 1979;173(1):103-9.

PMID:158405
Abstract

Anti-arrhythmic activity of some piperazine derivatives has been investigated upon cardiac arrythmia induced by aconitine in albinos rat. Among mono-substituted derivatives trimetazidine is active. Among di-substituted derivatives cinepazide and hydroxyzine are active but medibazine have a doubtful activity and piribedil and cinnarizine are devoid of activity.

摘要

研究了一些哌嗪衍生物对白化大鼠乌头碱诱发的心律失常的抗心律失常活性。在单取代衍生物中，曲美他嗪具有活性。在二取代衍生物中，桂哌齐特和羟嗪具有活性，但美地巴嗪活性存疑，而吡贝地尔和桂利嗪无活性。

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