Campbell Stephanie A, Gromeier Matthias
Deptartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Onkologie. 2005 Apr;28(4):209-15. doi: 10.1159/000084010. Epub 2005 Mar 31.
Recent advances in our understanding of virus-host interactions have fueled new studies in the field of oncolytic viruses. The first part of this review explained how cell-external factors, such as cellular receptors, influence tumor tropism and specificity of oncolytic virus candidates. In the second part of this review, we focus on cellinternal factors that mediate tumor-specific virus growth. An oncolytic virus must be able to replicate within cancerous cells and kill them without collateral damage to healthy surrounding cells. This desirable property is inherent to some proposed oncolytic viral agents or has been achieved by genetic manipulation in others.
我们对病毒与宿主相互作用的理解取得的最新进展推动了溶瘤病毒领域的新研究。本综述的第一部分解释了细胞外因素，如细胞受体，如何影响溶瘤病毒候选物的肿瘤嗜性和特异性。在本综述的第二部分，我们关注介导肿瘤特异性病毒生长的细胞内因素。溶瘤病毒必须能够在癌细胞内复制并杀死它们，而不会对周围健康细胞造成附带损害。这种理想的特性是一些提议的溶瘤病毒制剂所固有的，或者是通过对其他病毒的基因操作实现的。
