Cibicková Eubica, Cibicek Norbert, Zd'ánský Petr, Kohout Pavel
Charles University in Prague, Faculty of Medicine, Hradec Králové, Czech Republic.
Acta Medica (Hradec Kralove). 2004;47(4):273-5.
Even though coffee is not considered to be responsible for development of peptic ulcer, it may, however, prolong its healing by increasing acidity of gastric content. In our former work we observed a profound increase in sucrose permeability (above normal values) in healthy volunteers regularly drinking coffee for years. In literature, many factors affecting sucrose permeability have been described so far. None of them, however, studied the effect of coffee.
SUBJECTS, MATERIALS AND METHODS: 10 young asymptomatic habitual coffee drinkers were included in the study. The probands underwent SaLM test twice--first time without coffee restriction and second time after 48-hour coffee abstinence. The ingested SaLM solution comprised sucrose (25.0 g), lactulose (10.0 g), mannitol (2.0 g), xylose (2.0 g) and water (up to 100 ml). Urine was collected for five hours and the samples were analysed using gas chromatography. Results were compared with those of 8 young healthy volunteers not drinking coffee. Permeability for sucrose was significantly higher in the group of habitual coffee drinkers in comparison with non-coffee drinkers (p < 0.01). After 48-hour coffee abstinence sucrose excretion decreased significantly (p < 0.05) to a level not differing from that of non-coffee drinkers (p = 0.54).
Our results indicate that coffee may damage gastroduodenal mucosa in habitual coffee drinkers. In a time period of 48 hours the gastroduodenal mucosa is capable of a significant regeneration.
尽管咖啡不被认为是导致消化性溃疡的原因，但它可能会通过增加胃内容物的酸度来延长溃疡的愈合时间。在我们之前的研究中，我们观察到多年来经常喝咖啡的健康志愿者的蔗糖渗透性显著增加（高于正常值）。迄今为止，文献中已经描述了许多影响蔗糖渗透性的因素。然而，其中没有一项研究过咖啡的影响。
研究对象、材料与方法：本研究纳入了10名年轻的无症状习惯性咖啡饮用者。受试者接受了两次蔗糖-乳果糖-甘露醇（SaLM）试验——第一次试验时不限咖啡摄入，第二次试验是在禁食咖啡48小时后进行。摄入的SaLM溶液包含蔗糖（25.0克）、乳果糖（10.0克）、甘露醇（2.0克）、木糖（2.0克）和水（总量达100毫升）。收集尿液5小时，并使用气相色谱法对样本进行分析。将结果与8名不喝咖啡的年轻健康志愿者的结果进行比较。与不喝咖啡的人相比，习惯性咖啡饮用者组的蔗糖渗透性显著更高（p < 0.01）。禁食咖啡48小时后，蔗糖排泄量显著下降（p < 0.05），降至与不喝咖啡的人无差异的水平（p = 0.54）。
我们的结果表明，咖啡可能会损害习惯性咖啡饮用者的胃十二指肠黏膜。在48小时的时间段内，胃十二指肠黏膜能够进行显著的再生。
