Gotteland M, Cruchet S, Frau V, Wegner M E, Lopez R, Herrera T, Sanchez A, Urrutia C, Brunser O
Gastroenterology Unit, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile.
Dig Liver Dis. 2002 Oct;34(10):702-6. doi: 10.1016/s1590-8658(02)80021-4.
Smoking is a risk factor for gastroduodenal ulcer and gastric adenocarcinoma. However, the pathophysiological mechanisms induced by acute cigarette smoking in the human gastric mucosa are poorly understood.
To evaluate the effect of acute cigarette smoking, alone or with alcohol, on the gastric permeability to sucrose, a specific marker of mucosal damage in the stomach.
Twenty healthy volunteers (8 smokers/12 non-smokers) were studied. Each fasted subject ingested 500 ml of a 20% sucrose solution and the amount of sucrose excreted in a 5-hour urine collection was measured by gas chromatography Four sucrose permeability tests were carried out: 1. basal, 2. while smoking 5 cigarettes, 3. after drinking 50 ml of a 40 degrees alcoholic beverage, 4. a combination of 2+3.
Sucrose excretion increased after alcohol ingestion (40.5 +/- 6.0 mg vs 143.1 +/- 28.9 mg, p = 0.002), but was not modified by acute cigarette smoking (34.4 +/- 5.9 mg). When alcohol and cigarettes were simultaneously consumed, the increase in alcohol-induced sucrose excretion was significantly reduced (73.1 +/- 16.6 mg, p = 0.03). Basal sucrose excretion was similar in smokers and non-smokers. However, in acute cigarette smoking, a decrease in sucrose excretion was observed in smokers (p = 0.02) but not in non-smokers.
These results indicate that acute cigarette smoking may tighten the gastric mucosa in habitual smokers and this is associated with a smaller increase of gastric permeability induced by alcohol.
吸烟是胃十二指肠溃疡和胃腺癌的危险因素。然而，急性吸烟在人胃黏膜中诱导的病理生理机制尚不清楚。
评估急性吸烟单独或与酒精共同作用对胃对蔗糖的通透性的影响，蔗糖是胃黏膜损伤的一种特异性标志物。
研究了20名健康志愿者（8名吸烟者/12名非吸烟者）。每个空腹受试者摄入500毫升20%的蔗糖溶液，并通过气相色谱法测量5小时尿液收集过程中排出的蔗糖量。进行了四项蔗糖通透性测试：1.基础测试；2.吸5支烟时；3.饮用50毫升40度酒精饮料后；4.2+3的组合。
摄入酒精后蔗糖排泄增加（40.5±6.0毫克对143.1±28.9毫克，p=0.002），但急性吸烟对其无影响（34.4±5.9毫克）。同时摄入酒精和香烟时，酒精诱导的蔗糖排泄增加显著减少（73.1±16.6毫克，p=0.03）。吸烟者和非吸烟者的基础蔗糖排泄相似。然而，在急性吸烟时，吸烟者的蔗糖排泄减少（p=0.02），而非吸烟者则未出现这种情况。
这些结果表明，急性吸烟可能会使习惯性吸烟者的胃黏膜收紧，这与酒精引起的胃通透性增加幅度较小有关。
