Doyle William J, Skoner David P, Gentile Deborah
Allegheny Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA.
Curr Allergy Asthma Rep. 2005 May;5(3):173-81. doi: 10.1007/s11882-005-0034-8.
Identification of a pharmacologically targeted mediator of the common cold is a desirable, but, to date, elusive goal of current research. The roles of various mediators, such as histamine, leukotrienes, bradykinin, and, more recently, chemokines and cytokines, in the pathophysiology and development of complications of the common cold are the subject of previous and current investigations. Establishing causality of a mediator in the common cold has been difficult for a number of reasons, including the limitations of our research tools and protocols and the complexity of the inflammatory and immune pathways that participate during the common cold. The available evidence for mediation of the common cold is the subject of this manuscript.
鉴定普通感冒的药理学靶向介质是当前研究中一个理想但迄今为止难以实现的目标。各种介质,如组胺、白三烯、缓激肽,以及最近的趋化因子和细胞因子,在普通感冒的病理生理学和并发症发展中的作用是以往和当前研究的主题。由于多种原因,包括我们研究工具和方案的局限性以及普通感冒期间参与的炎症和免疫途径的复杂性,确定介质在普通感冒中的因果关系一直很困难。本文将讨论普通感冒介质的现有证据。