Van Cauwenberge P B, van Kempen M J, Bachert C
Dept. of Otorhinolaryngology, Ghent University Hospital, Belgium.
Acta Otorhinolaryngol Belg. 2000;54(3):397-401.
Upper respiratory tract infections are one of the most common infectious diseases in man and are mainly caused by rhinoviruses. A rhinoviral cold is characterized by a neutrophilic inflammatory reaction with relatively mild symptoms that rather result from the host inflammatory response to the virus than from a direct viral cytotoxic effect. As regulators of chemotaxis, transmigration and activators of inflammatory and immunocompetent cells, cytokines and mediators were shown to play a crucial role in the pathogenesis of a rhinovirus infection.
上呼吸道感染是人类最常见的传染病之一，主要由鼻病毒引起。鼻病毒感冒的特征是嗜中性粒细胞炎症反应，症状相对较轻，这些症状更多是由宿主对病毒的炎症反应引起，而非直接的病毒细胞毒性作用所致。作为趋化性、迁移的调节因子以及炎症和免疫活性细胞的激活剂，细胞因子和介质在鼻病毒感染的发病机制中起着关键作用。
