使用新型硬化剂对内痔进行硬化治疗。与结扎术和切除术的比较。
Sclerosing therapy of internal hemorrhoids with a novel sclerosing agent. Comparison with ligation and excision.
作者信息
Takano M, Iwadare J, Ohba H, Takamura H, Masuda Y, Matsuo K, Kanai T, Ieda H, Hattori Y, Kurata S, Koganezawa S, Hamano K, Tsuchiya S
机构信息
Coloproctology Center, Takano Hospital, 4-2-88 Obiyama, Kumamoto 862-0924, Japan.
出版信息
Int J Colorectal Dis. 2006 Jan;21(1):44-51. doi: 10.1007/s00384-005-0771-0. Epub 2005 Apr 21.
BACKGROUND AND AIMS
Patients with prolapsing internal hemorrhoids were treated with a novel sclerosing agent (OC-108), and the results were compared with surgery of ligation and excision.
PATIENTS AND METHODS
This study included 20 years or older patients with prolapsing internal hemorrhoids who visited ten medical institutions in Japan from October 2000 to October 2002. Investigation on surgery was also performed.
RESULTS
Comparing OC-108 and surgery in patients with third- and fourth-degree internal hemorrhoids according to the Goligher's classification, for which surgery has been generally indicated, at 28 days after treatment, the disappearance rate of prolapse was similar between OC-108 and surgery, 94% (75/80 patients) and 99% (84/85 patients), respectively. The 1-year recurrence rate was 16% (12/73 patients) in the OC-108 group, and this value was satisfactory because of its less invasive nature while it was more or less higher compared with 2% (2/81 patients) in the surgery group. The incidences of pain and bleeding were lower in the OC-108 group.
CONCLUSIONS
OC-108 is a useful alternative treatment for hemorrhoids.
背景与目的
采用一种新型硬化剂（OC - 108）治疗内痔脱垂患者，并将结果与结扎和切除术进行比较。
患者与方法
本研究纳入了2000年10月至2002年10月期间在日本十家医疗机构就诊的年龄在20岁及以上的内痔脱垂患者。同时也对手术情况进行了调查。
结果
根据戈利格尔分类法，对通常建议进行手术的三度和四度内痔患者比较OC - 108和手术治疗效果。治疗后28天，OC - 108组和手术组的脱垂消失率相似，分别为94%（80例患者中的75例）和99%（85例患者中的84例）。OC - 108组的1年复发率为16%（73例患者中的12例），由于其侵入性较小，该值令人满意，不过与手术组的2%（81例患者中的2例）相比略高。OC - 108组的疼痛和出血发生率较低。
结论
OC - 108是一种治疗痔疮的有效替代疗法。
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