Bouzahzah Boumediene, Jelicks Linda A, Morris Stephen A, Weiss Louis M, Tanowitz Herbert B
Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Parasitol Res. 2005 Jun;96(3):184-7. doi: 10.1007/s00436-005-1331-9. Epub 2005 Apr 21.
Risedronate, a bisphosphonate, was used to treat CD-1 mice infected with the Brazil strain of Trypanosoma cruzi. When given by subcutaneous injection 3 times/week, there was a significant reduction in mortality, however, the myocardial pathology and right ventricular dilation was unchanged in these mice compared to control animals. In C57BL/6 mice infected with the Tulahuen strain, there was no change in mortality in response to risedronate treatment. These data suggest that this class of compounds has activity against T. cruzi in vivo and illustrate the utility of imaging and pathologic studies as adjuncts in the evaluation of therapeutic compounds as treatments for experimental Chagas' disease. In addition, it underscores the need to use different strains of T. cruzi.
利塞膦酸盐，一种双膦酸盐，被用于治疗感染克氏锥虫巴西株的CD - 1小鼠。当每周皮下注射3次时，死亡率显著降低，然而，与对照动物相比，这些小鼠的心肌病理和右心室扩张情况没有变化。在感染图拉亨株的C57BL / 6小鼠中，利塞膦酸盐治疗对死亡率没有影响。这些数据表明这类化合物在体内对克氏锥虫有活性，并说明了成像和病理研究作为辅助手段在评估治疗化合物作为实验性恰加斯病治疗方法中的作用。此外，它强调了使用不同克氏锥虫株的必要性。
