Teixeira Mauro M, Gazzinelli Ricardo T, Silva João S
Departmento Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, 31270-901, Belo Horizonte, MG, Brazil.
Trends Parasitol. 2002 Jun;18(6):262-5. doi: 10.1016/s1471-4922(02)02283-3.
The inflammatory response that follows the infection with Trypanosoma cruzi is essential for host resistance to infection but is also responsible for the diverse pathology observed in Chagas disease. Here, we examine the stimuli and mechanisms underlying chemokine production following infection in vitro and in vivo, and the ability of chemokines to coordinate the influx of inflammatory and immune cells to the site of parasite infection, and to control T. cruzi growth.
克氏锥虫感染后引发的炎症反应对于宿主抵抗感染至关重要，但也是恰加斯病中观察到的多种病理变化的原因。在此，我们研究了体外和体内感染后趋化因子产生的刺激因素和机制，以及趋化因子协调炎症和免疫细胞流入寄生虫感染部位并控制克氏锥虫生长的能力。
