用氙 - 133进行的脑血流量研究在动静脉畸形中的应用：一项方法学研究。

CBF studies with Xenon-133 in arteriovenous malformations: a methodological study.

作者信息

Brawanski A, Meixensberger J, Holzschuh M, Prohovnik I, Ullrich W

机构信息

Neurosurgical University Clinic, Würzburg, Fed. Rep. of Germany.

出版信息

Neurosurg Rev. 1992;15(1):51-5.

PMID:1584438

Abstract

A new model for the two dimensional rCBF technique using the inhalation of Xenon 133 was tested in patients with arteriovenous malformations. It was hypothetized that, in contrast to the conventional CBF model, it corrects for the artifactual shunt flow through the AVM and thus yields physiological CBF data. Four regions of interest (AVM, contralateral to AVM, ipsilateral hemisphere, contralateral hemisphere) were defined in 17 patients with AVMs and analyzed for differences in grey matter flow (F1). In contrast to the conventional CBF model, the new model shows a decreased flow over the AVM area, corresponding to the results of Xenon CT and SPECT. Furthermore, the blood pool parameter P4 is very sensitive to the location of the AVM. Thus further investigations of the hemodynamics of AVMs with this model are encouraged.

摘要

一种使用氙 133 吸入法的二维脑血流量（rCBF）技术新模型在患有动静脉畸形的患者中进行了测试。据推测，与传统的脑血流量模型不同，该模型可校正通过动静脉畸形的假性分流，从而得出生理性脑血流量数据。在 17 例患有动静脉畸形的患者中定义了四个感兴趣区域（动静脉畸形、动静脉畸形对侧、同侧半球、对侧半球），并分析了灰质血流量（F1）的差异。与传统的脑血流量模型相比，新模型显示动静脉畸形区域的血流量降低，这与氙 CT 和单光子发射计算机断层扫描（SPECT）的结果一致。此外，血池参数 P4 对动静脉畸形的位置非常敏感。因此，鼓励使用该模型对动静脉畸形的血流动力学进行进一步研究。