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[2002 - 2003年海法养老院诺如病毒肠胃炎疫情]

[Outbreaks of norovirus gastroenteritis in nursing homes in Haifa, 2002-2003].

作者信息

Hefer Elioz, Rishpon Shmuel, Warman Sigal, Rubin Lisa

机构信息

Haifa District Health Office, Ministry of Health.

出版信息

Harefuah. 2005 Mar;144(3):187-90, 230.

Abstract

BACKGROUND

The incidence rate of Norovirus gastroenteritis is unknown since diagnostic tests are less readily available than for other agents. This pathogen is identified in less than 10% of acute gastrointestinal illness, despite the fact that recent reports from the United States attribute more than 50% of outbreaks to Noroviruses.

OBJECTIVES

This article describes three outbreaks of gastroenteritis caused by Noroviruses in three of Haifa's chronic care hospitals in order to raise awareness of its main role as a common agent in such outbreaks, and thereby include it in the differential diagnosis of outbreak investigations.

METHODS

Methods employed included epidemiological investigation of the outbreaks, sanitary inspection, personal interviews of hospital staff members, data collection from medical files and laboratory diagnosis by electron microscopy and RT-PCR of stool and vomitus for Noroviruses.

RESULTS

Noroviruses were identified in faeces and vomitus of patients in 2 outbreaks in chronic care hospitals in Haifa. Attack rates were high (20-41%). Proximity in time to these 2 outbreaks, and clinical and epidemiological findings lead us to attribute another outbreak in a third hospital to norovirus as well.

CONCLUSIONS

Physicians in institutions and the community should include Noroviruses in the differential diagnosis of outbreaks of gastroenteritis, particularly in cases where no other pathogens have been isolated. Timely requests for identification of Noroviruses are essential. The institution of good hygienic practices is important to prevent spread of this highly infectious agent.

摘要

背景

由于诊断测试不像针对其他病原体那样容易获得,诺如病毒肠胃炎的发病率尚不清楚。尽管美国最近的报告显示超过50%的疫情爆发是由诺如病毒引起的,但在不到10%的急性胃肠道疾病中能检测到这种病原体。

目的

本文描述了海法市三家慢性病护理医院中由诺如病毒引起的三起肠胃炎疫情,以提高人们对其作为此类疫情常见病原体的主要作用的认识,从而将其纳入疫情调查的鉴别诊断中。

方法

采用的方法包括对疫情进行流行病学调查、卫生检查、对医院工作人员进行个人访谈、从医疗档案中收集数据以及通过电子显微镜和对粪便及呕吐物进行逆转录聚合酶链反应(RT-PCR)检测诺如病毒进行实验室诊断。

结果

在海法市两家慢性病护理医院的两起疫情中,从患者的粪便和呕吐物中检测到了诺如病毒。发病率很高(20%-41%)。由于与这两起疫情在时间上接近,以及临床和流行病学调查结果,我们将第三家医院的另一起疫情也归因于诺如病毒。

结论

医疗机构和社区的医生在肠胃炎疫情的鉴别诊断中应考虑诺如病毒,特别是在未分离出其他病原体的情况下。及时要求检测诺如病毒至关重要。实施良好的卫生习惯对于防止这种高传染性病原体的传播很重要。

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