Petrović Mira, Hernando Maria Dolores, Díaz-Cruz M Silvia, Barceló Damià
Department of Environmental Chemistry, IIQAB-CSIC, 08034 Barcelona, Spain.
J Chromatogr A. 2005 Mar 4;1067(1-2):1-14. doi: 10.1016/j.chroma.2004.10.110.
Pharmaceutical residues are environmental contaminants of recent concern and the requirements for analytical methods are mainly dictated by low concentrations found in aqueous and solid environmental samples. In the current article, a review of the liquid chromatography-tandem mass spectrometry (LC-MS/MS) based methods published so far for the determination of pharmaceuticals in the environment is presented. Pharmaceuticals included in this review are antibiotics, non-steroidal anti-inflammatory drugs, beta-blockers, lipid regulating agents and psychiatric drugs. Advanced aspects of current LC-MS/MS methodology, including sample preparation and matrix effects, are discussed.
药物残留是近期备受关注的环境污染物，分析方法的要求主要取决于在水性和固体环境样品中发现的低浓度。在本文中，对迄今为止发表的基于液相色谱 - 串联质谱（LC-MS/MS）的环境中药物测定方法进行了综述。本综述涵盖的药物包括抗生素、非甾体抗炎药、β受体阻滞剂、脂质调节剂和精神药物。讨论了当前LC-MS/MS方法的先进方面，包括样品制备和基质效应。
