Zhang Zhiming, Sun Shuyan, Wang Shouchen, Ji Wenyue, Guan Chao
Department of Otorhinolaryngology, First Hospital, China Medical University, Shenyang, 110003, China.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Jan;19(2):78-81.
To study the expression and significance of Eotaxin gene in nasal mucosa of guinea pig sensitized by fungal allergen.
Alternaria alternata sensitized guinea pigs used as animal model of allergic rhinitis (AR). The changes in the nasal mucosa were studied by pathological method and the Eotaxin gene were studied by In Situ Hybridization.
The behavior science score of experimental group was significant higher than the controls group. Plenty eosinophils were found in lamina propria of nasal mucosa of experimental group. Eotaxin gene is expressed in lamina propria of nasal mucosa of experimental group. The controls group had not positive expression.
Eotaxin gene is expressed at high levels in nasal mucosa of fungal allergic rhinitis in the guinea pig. Plenty eosinophils were found in nasal mucosa. We considered that Eotaxin gene and eosinophils could play a key role in fungal allergic rhinitis.
研究嗜酸性粒细胞趋化因子（Eotaxin）基因在真菌变应原致敏豚鼠鼻黏膜中的表达及意义。
以链格孢致敏豚鼠作为变应性鼻炎（AR）动物模型。采用病理学方法研究鼻黏膜的变化，采用原位杂交法研究Eotaxin基因。
实验组行为学评分显著高于对照组。实验组鼻黏膜固有层发现大量嗜酸性粒细胞。Eotaxin基因在实验组鼻黏膜固有层表达。对照组无阳性表达。
Eotaxin基因在豚鼠真菌变应性鼻炎鼻黏膜中高水平表达。鼻黏膜中发现大量嗜酸性粒细胞。我们认为Eotaxin基因和嗜酸性粒细胞在真菌变应性鼻炎中可能起关键作用。
