[The expression of p21(WAF1/CIP1) and PCNA in hypopharyngeal and laryngeal squamous cell carcinomas].

OBJECTIVE

ln order to evaluate the significance of the expression of p21(WAF1/CIP1) and PCNA (proliferating cell nuclear antigen) in hypopharyngeal and laryngeal squamous cell carcinoma.

METHOD

Ninety-three patients who accepted operations for hypopharyngeal and laryngeal squamous cell carcinoma from 1998 to 2003 were included in this study, 45 cases were hypopharyngeal cancer, 25 cases were supraglottic cancer, 23 cases were glottic cancer. The clinical and histopathological features of these patients were reviewed. The Envision immunohistochemistry method was utilized to stain these faculties.

RESULT

The expression of p21(WAF1/CIP1) had no correlate with differentiation, N stage, metastasis, survival, recurrence and laryngeal site of involvement. However, significantly correlated with T stage of hypopharyngeal and laryngeal squamous cell carcinoma, also correlated with prognosis of hypopharyngeal and laryngeal squamous cell carcinoma. The percentage of PCNA labeled cells showed the statistically significant with clinical and N stage, but no significance was found among other clinicopathological parameter and PCNA staining intensity.

CONCLUSION

p21(WAF1/CIP1), PCNA play important roles in the progression of hypopharyngeal and laryngeal squamous cell carcinoma and are possible prognostic discriminators in hypopharyngeal and laryngeal squamous cell carcinoma.