Wee B E, Anderson K D, Kouchis N S, Turek F W
Department of Psychology, Tulane University, New Orleans, LA 70118.
Neurosci Lett. 1992 Mar 30;137(2):211-5. doi: 10.1016/0304-3940(92)90406-w.
The cholinergic agonist, carbachol, induces phase-dependent shifts in the timing of the circadian rhythm of locomotor activity (CRLA). The effects of carbachol injections into the lateral ventricles of hamsters were compared between circadian times that produce phase delays vs. phase advances in the CRLA. The shape of the dose-response curves and the ED50 for carbachol injections were similar for the two injection times. The second experiment demonstrated the dose-dependence of phase advances produced by carbachol injections into the area of the suprachiasmatic nucleus. These results indicate that carbachol exerts similar dose-dependent actions for both phases advances and phase delays.
胆碱能激动剂卡巴胆碱可诱导运动活动昼夜节律（CRLA）的时间出现相位依赖性变化。比较了在导致CRLA相位延迟与相位提前的昼夜时间点，向仓鼠侧脑室注射卡巴胆碱的效果。两次注射时间的卡巴胆碱剂量-反应曲线形状和半数有效剂量（ED50）相似。第二项实验证明了向视交叉上核区域注射卡巴胆碱所产生的相位提前的剂量依赖性。这些结果表明，卡巴胆碱对相位提前和相位延迟均发挥相似的剂量依赖性作用。
