卡巴胆碱可使去卵巢大鼠的昼夜活动节律发生相位偏移。

Carbachol phase shifts circadian activity rhythms in ovariectomized rats.

作者信息

Mistlberger R E, Rusak B

出版信息

Neurosci Lett. 1986 Dec 23;72(3):357-62. doi: 10.1016/0304-3940(86)90541-0.

Abstract

Ovariectomy in the rat abolishes alpha-bungarotoxin (alpha-BTX) binding within the suprachiasmatic nucleus (SCN), a putative circadian pacemaker, and markedly reduces cholinergic activation of SCN cells. Circadian rhythms of running wheel activity were monitored continuously in intact male and female and chronically ovariectomized rats before and after intraventricular carbachol injections. Carbachol produced similar phase shifts of the free-running rhythms in all groups. The results suggest that carbachol can influence the circadian system of rats by activation of cholinergic receptor sites independent of those binding alpha-BTX within the SCN.

摘要

大鼠卵巢切除可消除视交叉上核（SCN，一种假定的昼夜节律起搏器）内的α-银环蛇毒素（α-BTX）结合，并显著降低SCN细胞的胆碱能激活。在完整的雄性和雌性大鼠以及慢性卵巢切除的大鼠中，在脑室内注射卡巴胆碱前后，连续监测转轮活动的昼夜节律。卡巴胆碱在所有组中产生了类似的自由运转节律相移。结果表明，卡巴胆碱可通过激活胆碱能受体位点来影响大鼠的昼夜节律系统，而这些受体位点独立于SCN内与α-BTX结合的位点。