Mitwally Mohamed F M, Bhakoo Hemlata S, Crickard Kent, Sullivan Michael W, Batt Ronald E, Yehl John
Department of Gynecology and Obstetrics, School of Medicine and Health Sciences, University at Buffalo, State University of New York (SUNY), 219 Bryant Street, Buffalo, New York 14222, USA.
J Assist Reprod Genet. 2005 Feb;22(2):57-63. doi: 10.1007/s10815-005-1494-4.
Most studies reported estradiol (E2) levels attained on day of hCG administration when investigating effect of E2 on IVF outcome. We studied whether a relationship exists between the area under the curve for E2 levels (AUC-E2) and E2 levels on hCG day during IVF-ET.
Retrospectively, we analyzed data for 313 patients who completed one IVF-ET cycle each. Patients were sorted according to AUC-E2 levels. Then we compared between each patient's own AUC-E2 and the corresponding E2 level on hCG day for the same patient.
Although overall AUC-E2 correlated positively with E2 levels on hCG day, there was no consistent correlation between individual patients.
AUC-E2 reflects more accurately the amount of E2 produced by the follicles during controlled ovarian hyperstimulation. The absence of a uniform correlation between AUC-E2 and E2 on hCG day may result in different conclusions when studying outcomes of IVF treatment.
大多数研究在调查雌二醇（E2）对体外受精结局的影响时，报告的是注射人绒毛膜促性腺激素（hCG）当天达到的E2水平。我们研究了在体外受精-胚胎移植（IVF-ET）过程中，E2水平曲线下面积（AUC-E2）与hCG日的E2水平之间是否存在关联。
我们回顾性分析了313例分别完成一个IVF-ET周期的患者的数据。根据AUC-E2水平对患者进行分类。然后比较每位患者自身的AUC-E2与同一患者hCG日的相应E2水平。
尽管总体AUC-E2与hCG日的E2水平呈正相关，但个体患者之间不存在一致的相关性。
AUC-E2更准确地反映了控制性卵巢刺激过程中卵泡产生的E2量。AUC-E2与hCG日的E2之间缺乏一致的相关性，可能导致在研究IVF治疗结局时得出不同的结论。
