Bocci Elena Bartoloni, Delle Monache Francesco, Angrisani Monica Cesarotti Claudio, Gerli Roberto
Sezione di Medicina Interna e Scienze Oncologiche, Centro per lo Studio delle Malattie Reumatiche, Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi, Perugia.
Recenti Prog Med. 2005 Feb;96(2):65-9.
Cardiovascular disease is the commonest cause of premature mortality in rheumatoid arthritis and several data have shown that rheumatoid arthritis is an independent risk factor for the development of atherosclerotic disease. In last years it has become evident that atherosclerosis is an immune-mediated inflammatory disorder sharing a number of pathogenic features with rheumatoid arthritis. It is conceivable, therefore, that chronically raised concentrations of proinflammatory cytokines and pathological immune response characterizing rheumatoid arthritis may play a key role in inducing acceleration of atherosclerotic processes and, consequently, in the development of cardiovascular disease in these patients.
心血管疾病是类风湿关节炎患者过早死亡的最常见原因，多项数据表明类风湿关节炎是动脉粥样硬化疾病发生的独立危险因素。近年来，越来越明显的是，动脉粥样硬化是一种免疫介导的炎症性疾病，与类风湿关节炎具有许多致病特征。因此，可以想象，类风湿关节炎所特有的促炎细胞因子浓度长期升高和病理性免疫反应，可能在加速动脉粥样硬化进程中起关键作用，进而在这些患者心血管疾病的发生中起关键作用。
