番薯毒素A-E，来自苏里南雨林的鳞蕊番薯叶片中的具有细胞毒性的大环糖脂类化合物。

Ipomoeassins A-E, cytotoxic macrocyclic glycoresins from the leaves of Ipomoea squamosa from the Suriname rainforest.

作者信息

Cao Shugeng, Guza Rebecca C, Wisse Jan H, Miller James S, Evans Randy, Kingston David G I

机构信息

Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.

出版信息

J Nat Prod. 2005 Apr;68(4):487-92. doi: 10.1021/np049629w.

DOI:10.1021/np049629w

PMID:15844934

Abstract

The new glycoresins, ipomoeassins A-E (1-5), have been isolated from the leaves of Ipomoea squamosa. The structures were elucidated by spectroscopic analyses and chemical transformations. The absolute configurations of C-5 (ipomoeassins 3-5) and C-11 (ipomoeassins 1 and 2) were determined by their derivatives with (R)- and (S)-MPA. All the isolates were active in the A2780 human ovarian cancer cell line assay, and 4 showed the highest activity with an IC(50) value of 35 nM.

摘要

新型糖脂类化合物，番薯苦素A - E（1 - 5），已从鳞蕊甘薯的叶子中分离出来。通过光谱分析和化学转化确定了其结构。C - 5（番薯苦素3 - 5）和C - 11（番薯苦素1和2）的绝对构型通过它们与（R）-和（S）-MPA的衍生物来确定。所有分离物在A2780人卵巢癌细胞系试验中均具有活性，其中4表现出最高活性，IC(50)值为35 nM。