Cao Shugeng, Guza Rebecca C, Wisse Jan H, Miller James S, Evans Randy, Kingston David G I
Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
J Nat Prod. 2005 Apr;68(4):487-92. doi: 10.1021/np049629w.
The new glycoresins, ipomoeassins A-E (1-5), have been isolated from the leaves of Ipomoea squamosa. The structures were elucidated by spectroscopic analyses and chemical transformations. The absolute configurations of C-5 (ipomoeassins 3-5) and C-11 (ipomoeassins 1 and 2) were determined by their derivatives with (R)- and (S)-MPA. All the isolates were active in the A2780 human ovarian cancer cell line assay, and 4 showed the highest activity with an IC(50) value of 35 nM.
新型糖脂类化合物，番薯苦素A - E（1 - 5），已从鳞蕊甘薯的叶子中分离出来。通过光谱分析和化学转化确定了其结构。C - 5（番薯苦素3 - 5）和C - 11（番薯苦素1和2）的绝对构型通过它们与（R）-和（S）-MPA的衍生物来确定。所有分离物在A2780人卵巢癌细胞系试验中均具有活性，其中4表现出最高活性，IC(50)值为35 nM。
