毛香乙素，一种来自杜鹃兰的吡咯里西啶生物碱。
Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata.
作者信息
Ikeda Yoshitaka, Nonaka Hikaru, Furumai Tamotsu, Igarashi Yasuhiro
机构信息
Pharmaceuticals Research Unit, Mitsubishi Pharma Corporation, 2-25-1, Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan.
出版信息
J Nat Prod. 2005 Apr;68(4):572-3. doi: 10.1021/np049650x.
PMID:15844951
Abstract
A new pyrrolizidine alkaloid, cremastrine (1), was isolated from the bulbs of Cremastra appendiculata. Its configuration was determined by spectroscopic and chemical analyses. Compound 1 inhibited the binding of tritium-labeled N-methylscopolamine to the muscarinic M3 receptor with a K(i) value of 126 nM.
摘要
从杜鹃兰的鳞茎中分离出一种新的吡咯里西啶生物碱，杜鹃兰碱（1）。通过光谱和化学分析确定了其结构。化合物1抑制氚标记的N-甲基东莨菪碱与毒蕈碱M3受体的结合，其抑制常数（K(i)）值为126 nM。
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