Campo Pablo, Maestú Fernando, Capilla Almudena, Fernández Santiago, Fernández Alberto, Ortiz Tomás
Centro de Magnetoencefalografía Dr Pérez-Modrego, Pabellón 8, Facultad de Medicina, Universidad Complutense de Madrid, 28040, Madrid, Spain.
Eur J Neurosci. 2005 Mar;21(6):1741-8. doi: 10.1111/j.1460-9568.2005.03943.x.
Animal studies have suggested that working memory may be affected after lesions in the medial temporal lobe, although this assumption has not been corroborated by neuropsychological studies in humans. However, very recently, several functional neuroimaging studies in humans have successfully observed activation of the medial temporal lobe during working memory tasks. The main aim of this study was to investigate the contribution of the medial temporal lobe to the encoding process in spatial working memory. To address this issue we registered the neuromagnetic brain patterns of eight adult volunteers while they performed a spatial working memory task and more perceptual task using identical stimuli. After a initial phase (between 200 and 400 ms) without differences in activation, the medial temporal lobe showed a sustained activity, more evident in the right hemisphere, lasting up to 800 ms during the encoding stage of the spatial working memory task, while the activation in the perceptual task terminated earlier (approximately 400 ms after stimulus onset). The finding of a continued activation of the medial temporal lobe strongly suggests the contribution of this brain region to encoding operations in working memory.
动物研究表明，内侧颞叶受损后工作记忆可能会受到影响，尽管这一假设尚未得到人类神经心理学研究的证实。然而，最近，一些针对人类的功能性神经影像学研究成功观察到在工作记忆任务期间内侧颞叶的激活。本研究的主要目的是探讨内侧颞叶在空间工作记忆编码过程中的作用。为解决这一问题，我们记录了八名成年志愿者在执行空间工作记忆任务和使用相同刺激的更多感知任务时的脑磁图模式。在最初阶段（200至400毫秒之间）激活无差异之后，内侧颞叶表现出持续活动，在右半球更为明显，在空间工作记忆任务的编码阶段持续长达800毫秒，而感知任务中的激活在更早的时候（刺激开始后约400毫秒）就终止了。内侧颞叶持续激活的发现强烈表明该脑区对工作记忆中的编码操作有作用。
