Coles G C, Rhodes A C, Wolstenholme A J
Department of Clinical Veterinary Science, University of Bristol, Langford House, Bristol BS40 5DU, UK.
Vet Parasitol. 2005 May 15;129(3-4):345-7. doi: 10.1016/j.vetpar.2005.02.002.
Lambs infected with two isolates, one British and one American, of Haemonchus contortus were treated with increasing doses of ivermectin. Eggs from the highest dose that had not eliminated the infection were cultured and larvae used to infect another lamb. After three generations the H. contortus was resistant to 0.2 mg/kg ivermectin. The results stress the ease with which ivermectin resistance can be selected if high selection pressure is applied.
用两种捻转血矛线虫分离株（一种来自英国，一种来自美国）感染羔羊，然后用递增剂量的伊维菌素对其进行治疗。对未消除感染的最高剂量所产的虫卵进行培养，并用孵出的幼虫感染另一只羔羊。经过三代之后，捻转血矛线虫对0.2毫克/千克的伊维菌素产生了抗性。结果强调，如果施加高选择压力，伊维菌素抗性很容易被筛选出来。
