Patel A K, Patel K, Patel J
Department of Infectious Diseases, Sterling Hospital, Ahmedabad.
J Assoc Physicians India. 2004 Aug;52:666-9.
Highly active antiretroviral therapy (HAART) has resulted in dramatic declines in morbidity and mortality in HIV-I infected patients in the developed world. However, with the availability of generic antiretroviral treatments (ART) in India, a large number of patients now receive ART. Increase in experience with ART has led to the detection of drug-related toxicities. We report herein potentially fatal side effects associated with the use of nucleoside analogues in HIV treatment--hyperlactatemia and lactic acidosis/hepatic steatosis.
高效抗逆转录病毒疗法（HAART）已使发达国家感染HIV-1的患者的发病率和死亡率大幅下降。然而，随着印度可获得抗逆转录病毒通用治疗药物（ART），现在大量患者接受了ART治疗。随着ART治疗经验的增加，已检测到与药物相关的毒性反应。我们在此报告与HIV治疗中使用核苷类似物相关的潜在致命副作用——高乳酸血症和乳酸酸中毒/肝脂肪变性。
