腹腔注射后，表面电荷对脂质体包裹的庆大霉素在大鼠肝脏、脑、肺和肾脏中分布的影响。

The effect of surface charge on the disposition of liposome-encapsulated gentamicin to the rat liver, brain, lungs and kidneys after intraperitoneal administration.

作者信息

Abraham A M, Walubo A

机构信息

Department of Pharmacology, University of the Free State, P.O. Box 339 (G6), Bloemfontein 9300, South Africa.

出版信息

Int J Antimicrob Agents. 2005 May;25(5):392-7. doi: 10.1016/j.ijantimicag.2005.01.018.

DOI:10.1016/j.ijantimicag.2005.01.018

PMID:15848293

Abstract

The disposition of gentamicin to the normal rat brain, lung, kidney and liver was studied at intervals of 1, 2, 4, 6 and 8h after intraperitoneal injection of gentamicin encapsulated in positive, negative and neutral liposomes. Compared with the control, which was treated with free gentamicin, liposomes were associated with higher concentrations of gentamicin in the brain and liver, while concentrations were lower in the kidney. The average concentrations of gentamicin in the liver and the brain were highest with positive liposomes, while, gentamicin concentrations in the kidneys and lungs were not influenced by surface charge of the liposomes. These observations have important implications on the selective delivery of gentamicin to tissues and on the intraperitoneal route of administration.

摘要

在腹腔注射包封于正、负和中性脂质体中的庆大霉素后，于1、2、4、6和8小时的时间间隔研究了庆大霉素在正常大鼠脑、肺、肾和肝脏中的分布情况。与用游离庆大霉素治疗的对照组相比，脂质体使脑和肝脏中的庆大霉素浓度升高，而肾脏中的浓度降低。正脂质体使肝脏和脑中庆大霉素的平均浓度最高，而脂质体的表面电荷对肾脏和肺中庆大霉素的浓度没有影响。这些观察结果对于庆大霉素向组织的选择性递送以及腹腔给药途径具有重要意义。