Keizer K M, de Klerk M, Haase-Kromwijk B J J M, Weimar W
Dutch Transplantation Foundation, Erasmus Medical Center, Rotterdam, The Netherlands.
Transplant Proc. 2005 Mar;37(2):589-91. doi: 10.1016/j.transproceed.2004.12.096.
The shortage of kidneys from brain-dead donors for transplantation has made it necessary to look for alternatives. Living kidney donation is one possibility. However, because of ABO blood group incompatibility or immunological reasons, transplantation of kidneys from a living donor is not always possible. The seven Dutch kidney transplantation centers have developed a joint protocol for crossover, or paired donor exchange, kidney transplantation. To ensure a fair chance for all participating donor-recipient pairs, the Dutch Transplantation Foundation has developed an allocation algorithm to match compatible donor-recipient pairs. A crossover match is performed every 3 months. The computer program developed by the Dutch Transplantation Foundation to match compatible donor-recipient pairs calculates the match probability (MP) of every potential recipient. The MP takes into account the peak panel-reactive antibodies (%PRA) of the recipient, the incidence within the crossover donor population of (compatible) ABO blood group, and HLA unacceptables of the recipient. The potential recipient with the lowest MP, in other words, the recipient with the smallest chance of finding a compatible donor in the pool, is ranked first. Until now, three matches have been performed in the Netherlands. A total of 53 pairs from all seven Dutch transplantation centers have participated. For 22 of the pairs a compatible donor-recipient pair was found.
脑死亡供体的肾脏用于移植时短缺，因此有必要寻找替代方案。活体肾捐赠是一种可能。然而，由于ABO血型不相容或免疫原因，活体供体的肾脏移植并非总是可行。荷兰的七个肾脏移植中心已经制定了交叉或配对供体交换肾脏移植的联合方案。为确保所有参与的供体-受体对都有公平机会，荷兰移植基金会开发了一种分配算法来匹配相容的供体-受体对。每三个月进行一次交叉匹配。荷兰移植基金会开发的用于匹配相容供体-受体对的计算机程序会计算每个潜在受体的匹配概率（MP）。MP考虑了受体的峰值群体反应性抗体（%PRA）、交叉供体群体中（相容的）ABO血型的发生率以及受体的HLA不可接受情况。MP最低的潜在受体，换句话说，在库中找到相容供体机会最小的受体，排名第一。到目前为止，荷兰已经进行了三次匹配。来自荷兰所有七个移植中心的总共53对参与其中。在这些对中，有22对找到了相容的供体-受体对。
